The role of the cytokines IL-27 and IL-35 in cancer

Mathematical Biosciences and Engineering : MBE
Avner Friedman, Kang-Ling Liao

Abstract

The cancer-immune interaction is a fast growing field of research in biology, where the goal is to harness the immune system to fight cancer more effectively. In the present paper we review recent work of the interaction between T cells and cancer. CD8+ T cells are activated by IL-27 cytokine and they kill tumor cells. Regulatory T cells produce IL-35 which promotes cancer cells by enhancing angiogenesis, and inhibit CD8+ T cells via TGF-β production. Hence injections of IL-27 and anti-IL-35 are both potentially anti-tumor drugs. The models presented here are based on experimental mouse experiments, and their simulations agree with these experiments. The models are used to suggest effective schedules for drug treatment.

References

Oct 1, 1993·The Journal of Experimental Medicine·M J BrundaM K Gately
Jun 15, 1999·Toxicologic Pathology·B D CarT D Anderson
Mar 20, 2002·Cytokine & Growth Factor Reviews·Mario P Colombo, Giorgio Trinchieri
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Udaya K LiyanageDavid C Linehan
May 30, 2003·Pharmacological Reviews·K AsadullahH D Volk
Jan 2, 2004·Physics in Medicine and Biology·J ReayC J Kotre
Feb 12, 2004·Cancer Research·Masayuki HisadaTakayuki Yoshimoto
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rosalba SalcedoJon M Wigginton
Jul 7, 2005·Nature Reviews. Immunology·Christopher A Hunter
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dominik WolfChristian Marth
Jan 4, 2007·The Journal of Clinical Investigation·M Bishr OmaryStephen J Pandol
Apr 25, 2007·Acta Oto-laryngologica·Kenneth W KrossHans Jørgen Aarstad
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teruo KaigaHideaki Tahara
Aug 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laura StraussTheresa L Whiteside
Nov 23, 2007·Nature·Lauren W CollisonDario A A Vignali
Jun 21, 2008·Nature Reviews. Immunology·Dario A A VignaliCreg J Workman
Dec 18, 2008·International Journal of Cancer. Journal International Du Cancer·Yukari ShinozakiHiroki Yoshida
Jan 24, 2009·Immunological Reviews·Lauren W Collison, Dario A A Vignali
Sep 10, 2009·International Immunology·Shimon SakaguchiTomoyuki Yamaguchi
Oct 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ming-Yi HoKuang-Hui Sun
Feb 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shiguo ZhuShulin Li
May 11, 2010·Journal of Biomedicine & Biotechnology·Noriko MorishimaTakayuki Yoshimoto
Oct 5, 2010·Clinical & Developmental Immunology·Mingli XuTakayuki Yoshimoto
Dec 1, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kathrin EllerAnna M Wolf
Feb 15, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eijun ItakuraAlistair J Cochran
May 18, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Vandana ChaturvediDario A A Vignali
May 21, 2011·Journal of Experimental & Clinical Cancer Research : CR·Rui WangHaiquan Chen
May 31, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elia D Tait WojnoChristopher A Hunter
Nov 30, 2011·Cancer Research·Takashi TanikawaWeiping Zou
Dec 14, 2011·The Journal of Investigative Dermatology·Karin Loser, Stefan Beissert
Dec 17, 2011·Cancer Cell·John B MummMartin Oft
Feb 7, 2012·Nature Immunology·Lauren W CollisonDario A A Vignali
Mar 23, 2012·Nature Reviews. Immunology·Dmitry I GabrilovichVincenzo Bronte
Jul 6, 2012·Journal of Theoretical Biology·Barbara SzomolayAvner Friedman
Jul 21, 2012·Nature Immunology·Dario A A Vignali, Vijay K Kuchroo
Oct 18, 2012·Bulletin of Mathematical Biology·Duan ChenAvner Friedman
Oct 23, 2012·Journal of Cellular Physiology·Olga ZolochevskaMarxa L Figueiredo

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Citations

Mar 27, 2018·International Journal of Cancer. Journal International Du Cancer·Manouchehr TeymouriAmirhosein Sahebkar
Dec 29, 2020·The Journal of International Medical Research·Jing-Jing Zhu, Ning-Ning Shan
Mar 30, 2021·Frontiers in Cell and Developmental Biology·Xuefen LiWeilin Wang

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