The role of the endoplasmic reticulum stress in stemness, pluripotency and development

European Journal of Cell Biology
Kateřina KratochvílováPetr Vaňhara

Abstract

The molecular machinery of endoplasmic reticulum (ER) integrates various intracellular and extracellular cues to maintain homeostasis in diverse physiological or pathological scenarios. ER stress and the unfolded protein response (UPR) have been found to mediate molecular and biochemical mechanisms that affect cell proliferation, differentiation, and apoptosis. Although a number of reviews on the ER stress response have been published, comprehensive reviews that broadly summarize ER physiology in the context of pluripotency, embryonic development, and tissue homeostasis are lacking. This review complements the current ER literature and provides a summary of the important findings on the role of the ER stress and UPR in embryonic development and pluripotent stem cells.

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Citations

Dec 14, 2019·Molecular and Cellular Biochemistry·Kentaro Oh-HashiYoko Hirata
Jun 25, 2020·Biotechnology and Bioengineering·Brent M BijonowskiTeng Ma
Jul 28, 2019·Metallomics : Integrated Biometal Science·Lukáš MoráňPetr Vaňhara
Aug 21, 2020·Molecular and Cellular Biochemistry·Kentaro Oh-HashiYoko Hirata
Jul 28, 2017·Cellular and Molecular Life Sciences : CMLS·Alireza NoormohammadiDavid Vilchez
Jun 14, 2019·Stem Cells International·Bertal H AktasSüleyman Ergün
May 29, 2021·Developmental Biology·Jorge B AquinoLaura A Montaldo

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