The Role of the Environment in Eosinophilic Esophagitis

Clinical Reviews in Allergy & Immunology
Paul J DowlingBrooke I Polk

Abstract

Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disease with incompletely understood pathogenesis. Though disease manifestations were initially ascribed to a delayed reaction to food allergens, emerging evidence suggests that modifiable host factors and environmental allergen exposure may also play critical roles in the pathogenesis and ongoing manifestations of EoE. As with other atopic diseases, lack of early-life exposure to microbial pathogens leads to an immune tolerance defect and reprograms the commensal gut microflora toward a type 2 T helper (Th2) phenotype; the esophageal microbiota, a rich environment consisting of diverse bacterial species, is greatly altered by inflammation. Although multiple early life microbiome-altering factors are associated with EoE development, no causative, direct relationships have been identified. Interestingly, large, cross-sectional analyses of several populations identify an inverse relationship between Helicobacter pylori presence and EoE, likely via virulence factors that downregulate Th2 inflammation, though causality has not been proven. In regard to environmental allergens, some studies support seasonal variation in EoE diagnosis and flares, and EoE can be...Continue Reading

References

Apr 13, 1999·The American Journal of Surgical Pathology·S V WalshG T Furuta
Jan 3, 2001·The Journal of Clinical Investigation·A MishraM E Rothenberg
Feb 14, 2002·The Journal of Allergy and Clinical Immunology·Jonathan M SpergelChris A Liacouras
Oct 18, 2003·The Journal of Allergy and Clinical Immunology·Matthew I FoggJonathan M Spergel
Mar 16, 2004·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Mitchell KaplanAli Keshavarzian
Sep 7, 2005·Gastroenterology·Hiroko Saito AkeiMarc E Rothenberg
Nov 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K OnbasiF Sebik
Dec 20, 2005·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Chris A LiacourasJonathan E Markowitz
Mar 18, 2006·The Journal of Clinical Investigation·Amedeo AmedeiMarina de Bernard
Jun 24, 2006·Allergy·C A AkdisM Akdis
Jul 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Amir F KagalwallaB U K Li
Aug 19, 2007·Current Allergy and Asthma Reports·Martin D ChapmanAnna Pomés
Dec 13, 2007·The Journal of Allergy and Clinical Immunology·Carine BlanchardMarc E Rothenberg
Feb 26, 2009·The American Journal of Gastroenterology·Cristina AlmansaSami R Achem
Jul 7, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ganapathy A PrasadNicholas J Talley
Nov 21, 2009·Alimentary Pharmacology & Therapeutics·F J MoawadR K H Wong
Mar 31, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yun ShiQuan-Ming Zou
Apr 24, 2010·Journal of Leukocyte Biology·Madhavi RayapudiAnil Mishra
Nov 16, 2010·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·J StumphyR Rahhal
Jun 16, 2011·Digestive Diseases and Sciences·Alfredo J LucendoAngel Arias
Jul 9, 2011·The Journal of Clinical Investigation·Isabelle C ArnoldAnne Müller
Aug 3, 2011·European Journal of Pediatrics·Ruben RochaJorge Amil Dias
Dec 31, 2011·The Journal of Allergy and Clinical Immunology·Jonathan M SpergelChris A Liacouras
Mar 1, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Parm MaviAnil Mishra
May 24, 2012·Journal of Gastroenterology·Serge Alexander SorserHernando Lyons
Jun 30, 2012·The Journal of Allergy and Clinical Immunology·Jonathan M SpergelChris A Liacouras
Aug 28, 2012·The Journal of Allergy and Clinical Immunology·Marija Geroldinger-SimicBarbara Bohle
Nov 21, 2012·Journal of Clinical Gastroenterology·Yoram ElitsurYulia Dementieva
Feb 5, 2013·The Journal of Allergy and Clinical Immunology·Liliane De SwertDominique Bullens
Mar 23, 2013·Journal of Pediatric Gastroenterology and Nutrition·Elizabeth T JensenEvan S Dellon
Apr 10, 2013·The American Journal of Gastroenterology·Evan S DellonUNKNOWN American College of Gastroenterology
Jun 15, 2013·The Journal of Allergy and Clinical Immunology·Robert M Ramirez, Robert L Jacobs
Jul 23, 2013·Journal of Clinical Biochemistry and Nutrition·Kenji FurutaYoshikazu Kinoshita
Oct 29, 2013·Case Reports in Gastroenterology·Stephan MiehlkeAlex Straumann
May 6, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Glenn T FurutaJames J Lee
Jul 6, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Chelsea R SchlegelCarla M Davis
Jul 16, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Marcella C RadanoCorinne A Keet
Aug 27, 2014·Proceedings of the National Academy of Sciences of the United States of America·Andrew T StefkaCathryn R Nagler
Sep 14, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Alfredo J LucendoJosé M Tenias

❮ Previous
Next ❯

Citations

Aug 10, 2020·Annals of the New York Academy of Sciences·Michael DoulberisGerhard Rogler
Dec 20, 2018·Clinical Reviews in Allergy & Immunology·Shang-An ShuPatrick S C Leung
Dec 12, 2020·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Corey J KetchemEvan S Dellon
May 3, 2021·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Enrique La Orden IzquierdoUNKNOWN Working group on Eosinophilic esophagitis of the “Gastrosuroeste group” in Madrid
Jun 8, 2021·Seminars in Immunopathology·Luc BiedermannPhilipp Schreiner

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

Current Gastroenterology Reports
Thomas M Runge, Evan S Dellon
Clinical Reviews in Allergy & Immunology
Jesus R GuajardoEdward G Brooks
Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association
Evan S Dellon
The Journal of Allergy and Clinical Immunology
L C KottyanLisa J Martin
© 2022 Meta ULC. All rights reserved