The role of the extracellular signal-regulated kinase pathway in cerebellar abnormalities in schizophrenia

The Cerebellum
Svetlana V Kyosseva

Abstract

Recent postmortem and functional imaging studies have revealed that cerebellar abnormalities may play a role in the pathophysiology of schizophrenia. Cerebellum is a part of the cortical-subcortical-cerebellar circuitry that is involved in higher cognitive functions. Deficits in cognition, including information, executive functions, attention, emotion, and memory have been described in patients with schizophrenia. Given the pivotal role of mitogen-activated protein (MAP) kinase pathways in regulation of neuronal function and especially the role of extracellular-signal regulated kinase (ERK) in synaptic plasticity, cell survival, learning and memory, the importance of MAP kinases in schizophrenia is being increasingly recognized. In this mini-review is summarized recent evidence from human postmortem studies and the phencyclidine (PCP) pharmacological model of schizophrenia that ERK signaling pathway could contribute to the pathogenic events that occur in the cerebellum in schizophrenia.

Citations

Dec 3, 2005·The Cerebellum·Dennis J L G Schutter, Jack van Honk
Mar 6, 2013·Nucleic Acids Research·Shengjun HongMomiao Xiong
Apr 9, 2009·Schizophrenia Research·Amanda R BolbeckerWilliam P Hetrick
Jan 29, 2008·Psychiatry Research·Chad R EdwardsWilliam P Hetrick
Jun 7, 2005·Journal of Neurochemistry·Tim D WerryArthur Christopoulos
Apr 12, 2005·Journal of Chemical Neuroanatomy·Helena T Mueller, James H Meador-Woodruff
Feb 6, 2015·Neurology Research International·Menizibeya O WelcomeVladimir A Pereverzev
Nov 8, 2008·The American Journal of Pathology·Faris FarassatiAndreas Kurtz
Feb 22, 2017·Molecular Psychiatry·A Busquets-GarciaG Marsicano
Aug 17, 2020·Journal of Clinical Psychopharmacology·Bita VahdaniSaeideh Mazloomzadeh

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