The role of the flushing response in the relationship between alcohol consumption and insulin resistance

Alcoholism, Clinical and Experimental Research
Jin-Gyu JungMi-Kyeong Oh

Abstract

Facial flushing responses to drinking, because of intolerance to alcohol, are observed in some people, especially Asians. This study examined the role of flushing responses in the relationship between alcohol consumption and insulin resistance (IR). Participants in this cross-sectional analysis included 624 Korean men (80 nondrinkers, 306 nonflushing drinkers, and 238 flushing drinkers) who were free of cardiovascular disease and diabetes. Data on the flushing response to drinking and alcohol consumption were collected from medical records. IR was estimated using the Homeostasis Model Assessment (HOMA(IR) ). On the basis of comparisons with nondrinkers, the risk of IR according to the quantity of alcohol consumed per week was analyzed among nonflushers and flushers. After adjusting for age, exercise status, smoking status, BMI, waist circumference, blood pressure, high-density lipoprotein cholesterol, and triglycerides using a logistic regression model, we found a low risk of IR among nonflushers who consumed ≤4 drinks (1 drink = 14 g of alcohol) per week (OR = 0.3). In contrast, a higher risk of IR was associated with nonflushers who consumed >20 drinks per week (OR = 3.5). On the other hand, only a higher risk of IR was assoc...Continue Reading

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Citations

Mar 30, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Kyung-Yeol BaeJin-Sang Yoon
Jan 17, 2014·Alcoholism, Clinical and Experimental Research·Keisuke KuwaharaTetsuya Mizoue
Nov 27, 2014·Korean journal of family medicine·Seung-Won Oh
Jul 16, 2019·Korean journal of family medicine·Sami LeeJihan Kim
Jan 3, 2014·Physiological Reviews·Che-Hong ChenDaria Mochly-Rosen
May 28, 2020·Korean journal of family medicine·Soo Young Kim
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