Abstract
Facial flushing responses to drinking, because of intolerance to alcohol, are observed in some people, especially Asians. This study examined the role of flushing responses in the relationship between alcohol consumption and insulin resistance (IR). Participants in this cross-sectional analysis included 624 Korean men (80 nondrinkers, 306 nonflushing drinkers, and 238 flushing drinkers) who were free of cardiovascular disease and diabetes. Data on the flushing response to drinking and alcohol consumption were collected from medical records. IR was estimated using the Homeostasis Model Assessment (HOMA(IR) ). On the basis of comparisons with nondrinkers, the risk of IR according to the quantity of alcohol consumed per week was analyzed among nonflushers and flushers. After adjusting for age, exercise status, smoking status, BMI, waist circumference, blood pressure, high-density lipoprotein cholesterol, and triglycerides using a logistic regression model, we found a low risk of IR among nonflushers who consumed ≤4 drinks (1 drink = 14 g of alcohol) per week (OR = 0.3). In contrast, a higher risk of IR was associated with nonflushers who consumed >20 drinks per week (OR = 3.5). On the other hand, only a higher risk of IR was assoc...Continue Reading
References
Dec 1, 1991·Annals of Surgery·I H NordbackJ L Cameron
Jun 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N EnomotoA Takada
Nov 1, 1990·American Journal of Epidemiology·T L HolbrookD L Wingard
Dec 1, 1989·American Journal of Epidemiology·E J Feskens, D Kromhout
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Jan 1, 1983·Pharmacology, Biochemistry, and Behavior·Y MizoiI Ijiri
Jan 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A YoshidaM Ikawa
Jan 1, 1981·Alcoholism, Clinical and Experimental Research·D P AgarwalH W Goedde
Feb 8, 1997·BMJ : British Medical Journal·G Razay, K W Heaton
May 15, 1997·American Journal of Epidemiology·R LazarusS T Weiss
Sep 10, 1999·Diabetes Care·K TsumuraK Okada
Apr 13, 2000·Archives of Internal Medicine·U A AjaniJ E Manson
Jun 17, 2000·Diabetes Care·M WeiS N Blair
Nov 25, 2000·Diabetes Care·R A BellS M Haffner
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·C J Eriksson
Oct 9, 2001·American Journal of Epidemiology·W H KaoF L Brancati
Oct 12, 2004·Preventive Medicine·Richard SaitzDavid L Rosenbloom
Jun 13, 2006·Arquivos brasileiros de endocrinologia e metabologia·Bruno Geloneze, Marcos Antonio Tambascia
Aug 8, 2006·Journal of Korean Medical Science·Sihoon LeeDae Jung Kim
Feb 22, 2007·Current Neurovascular Research·Kenneth MaieseZhao Zhong Chong
Jun 26, 2007·Diabetes Care·James B MeigsEmelia J Benjamin
Aug 19, 2007·The Journal of Clinical Endocrinology and Metabolism·Lana M BellElizabeth A Davis
Dec 29, 2007·Journal of Korean Medical Science·Soo Geun KimHyun Ju Seo
Jun 14, 2008·The American Journal of Cardiology·Vaijinath S Kamanna, Moti L Kashyap
Apr 3, 2008·Mayo Clinic Proceedings·Ronald B Goldberg, Terry A Jacobson
Nov 28, 2008·Cancer Letters·Seiji IshiguroUNKNOWN JPHC Study Group
Apr 25, 2009·Diabetes Care·Kyong ParkDavid R Jacobs
Citations
Mar 30, 2012·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Kyung-Yeol BaeJin-Sang Yoon
Jan 17, 2014·Alcoholism, Clinical and Experimental Research·Keisuke KuwaharaTetsuya Mizoue
Nov 27, 2014·Korean journal of family medicine·Seung-Won Oh
Nov 27, 2014·Korean journal of family medicine·Hae Sun SuhJae Bum Ahn
Apr 6, 2013·Korean journal of family medicine·Seong Gu KimEo Chin Kim
Aug 2, 2013·Korean journal of family medicine·Eo-Chin KimJung-Sun Ryu
Jul 16, 2019·Korean journal of family medicine·Sami LeeJihan Kim
Jan 3, 2014·Physiological Reviews·Che-Hong ChenDaria Mochly-Rosen
May 28, 2020·Korean journal of family medicine·Soo Young Kim
May 28, 2020·Korean journal of family medicine·Jihan KimWon-Jin Lee
Oct 21, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Friedrich C Luft
Dec 6, 2017·Alcoholism, Clinical and Experimental Research·Cheol Min ShinHee-Jung Lee
Jan 13, 2018·Scientific Reports·Yoonsu ChoMin-Jeong Shin
Sep 9, 2020·European Journal of Pharmacology·Monika MittalNaibedya Chattopadhyay
Aug 28, 2021·Biology·Sien-Sing YangHsiao-Li Chuang