The role of the folate pathway in pancreatic cancer risk

PloS One
Shirisha ChittiboyinaBarbara A Hocevar

Abstract

Pancreatic cancer is the third leading cause of cancer related deaths in the United States. Several dietary factors have been identified that modify pancreatic cancer risk, including low folate levels. In addition to nutrition and lifestyle determinants, folate status may be influenced by genetic factors such as single nucleotide polymorphisms (SNPs). In the present study, we investigated the association between folate levels, genetic polymorphisms in genes of the folate pathway, and pancreatic cancer. Serum and red blood cell (RBC) folate levels were measured in pancreatic cancer and control subjects. Genotypes were determined utilizing Taqman probes and SNP frequencies between cases and controls were assessed using Fisher's exact test. Logistic regression was used to estimate the odds ratio (OR) and corresponding 95% confidence intervals (CIs) to measure the association between genotypes and pancreatic cancer risk. The association between folate levels and SNP expression was calculated using one-way ANOVA. Mean RBC folate levels were significantly lower in pancreatic cancer cases compared to unrelated controls (508.4 ± 215.9 ng/mL vs 588.3 ± 229.2 ng/mL, respectively) whereas serum folate levels were similar. Irrespective of ...Continue Reading

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Nov 10, 2018·Journal of Clinical Laboratory Analysis·Guodong XuLi Li
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Mar 12, 2021·Frontiers in Pharmacology·Kaiyuan ChenBicheng Chen
Jun 17, 2021·Cancer Chemotherapy and Pharmacology·Mikael ÖmanHelena Taflin

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Methods Mentioned

BETA
PCR
Assay

Software Mentioned

Illumina

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