The role of the glia limitans in ADP-induced pial arteriolar relaxation in intact and ovariectomized female rats

American Journal of Physiology. Heart and Circulatory Physiology
Hao-Liang XuDale A Pelligrino

Abstract

We examined whether the glia limitans (GL) influences pial arteriolar relaxation elicited in vivo by the purinergic (P(2)Y(1) receptor) agonist ADP in female rats, and whether that influence is altered in ovariectomized (Ovx) females. A validated model for GL injury was used, topical application of the gliotoxin L-alpha-aminoadipic acid (L-alphaAAA), 24 h before the study. In both intact and Ovx females, L-alphaAAA had no effect on responses to the NO donor, S-nitroso-N-acetyl penicillamine, but ADP-induced pial arteriolar dilations were significantly reduced (by 33-90%), compared with vehicle-treated controls. When N(G)-nitro-L-arginine (L-NNA) was administered to L-alphaAAA-treated rats, the ADP response was virtually lost in intact females, but no further reductions were observed in the Ovx rats. On the other hand, in L-alphaAAA-treated Ovx females, when the gap junction blocker, Gap 27, was subsequently added to the suffusate, ADP reactivity fell to very low levels. In vehicle-treated control rats, L-NNA and Gap 27 reduced ADP reactivity by approximately 50% in intact and Ovx females, respectively. An earlier study indicated that the endothelium was a key site of influence for L-NNA (intact) and Gap 27 (Ovx). Thus present a...Continue Reading

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Citations

Aug 2, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Francesco VetriDale A Pelligrino
Oct 5, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Chanannait PaisansathanDale A Pelligrino
Aug 8, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Charles W LefflerDilyara Tcheranova
May 17, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Qi XiCharles W Leffler
Feb 12, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Tetsu KawaguchiRaymond C Koehler
Dec 17, 2005·Journal of Applied Physiology·Raymond C KoehlerDavid R Harder
Feb 19, 2011·Seminars in Cell & Developmental Biology·Dale A PelligrinoHao-Liang Xu
May 1, 2007·Experimental Physiology·Hao-Liang Xu, Dale A Pelligrino
Dec 7, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Hao-Liang XuDale A Pelligrino
Dec 18, 2013·Pharmacological Reviews·Geoffrey Burnstock, Vera Ralevic
Oct 11, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Peter TothZoltan I Ungvari
Nov 6, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jianxiong LiuHelena Parfenova
Jul 14, 2006·Kidney International·I C VillarA Ahluwalia

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