The Role of the Gut-Brain Axis in Attention-Deficit/Hyperactivity Disorder

Gastroenterology Clinics of North America
Sarita A DamAlejandro Arias-Vasquez

Abstract

Genetic and environmental factors play a role in the cause and development of attention-deficit/hyperactivity disorder (ADHD). Recent studies have suggested an important role of the gut-brain axis (GBA) and intestinal microbiota in modulating the risk of ADHD. Here, the authors provide a brief overview of the clinical and biological picture of ADHD and how the GBA could be involved in its cause. They discuss key biological mechanisms involved in the GBA and how these may increase the risk of developing ADHD. Understanding these mechanisms may help to characterize novel treatment options via identification of disease biomarkers.

References

Jan 1, 1992·Progress in Growth Factor Research·N Y Ip, G D Yancopoulos
Jan 1, 1991·Progress in Brain Research·G Aston-JonesB Astier
Mar 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·S R PliszkaJ W Maas
Apr 1, 1996·Journal of the American Academy of Child and Adolescent Psychiatry·T SpencerS Griffin
Apr 9, 1999·Nature Neuroscience·K B ClarkR A Jensen
Nov 24, 1999·Biological Psychiatry·J Biederman, T Spencer
Nov 24, 1999·Biological Psychiatry·G Aston-JonesJ Cohen
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·H R Berthoud, W L Neuhuber
Jun 14, 2005·Biological Psychiatry·Stephen V FaraonePamela Sklar
Dec 22, 2006·Nature·Ruth E LeyJeffrey I Gordon
Jun 2, 2007·The American Journal of Psychiatry·Guilherme PolanczykLuis Augusto Rohde
Aug 28, 2007·Acta Paediatrica·Tania Das BanerjeeStephen V Faraone
Dec 15, 2007·Clinical Neuroscience Research·Adrian J Dunn
May 22, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jonathan Mill, Arturas Petronis
Sep 30, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Jessica Lasky-SuStephen V Faraone
Mar 3, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Viktória SimonIstván Bitter
Apr 18, 2009·Developmental Neuroscience·Nikos MakrisLarry J Seidman
Jun 10, 2009·Human Genetics·Ian R GizerIrwin D Waldman
Jan 1, 1981·Neurochemistry International·M Ebadi
Aug 18, 2009·Journal of Affective Disorders·Larry J KlassenPratap Chokka
Apr 10, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A V Keita, J D Söderholm
Jun 11, 2010·Journal of Developmental and Behavioral Pediatrics : JDBP·Daniel F ConnorKeith McBurnett
Jul 16, 2010·Journal of Attention Disorders·Amber L HowardWendy H Oddy
Mar 23, 2009·International Journal of Tryptophan Research : IJTR·Dawn M RichardDonald M Dougherty
Aug 4, 2010·Proceedings of the National Academy of Sciences of the United States of America·Carlotta De FilippoPaolo Lionetti
Sep 24, 2010·Postgraduate Medicine·Timothy E Wilens, Thomas J Spencer
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Rochellys Diaz HeijtzSven Pettersson
Mar 23, 2011·Trends in Neurosciences·Eitan OkunMark P Mattson
Mar 26, 2011·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Henrik LarssonEdward D Barker
Jul 14, 2011·Nature Reviews. Neuroscience·Emeran A Mayer
Jul 23, 2011·Current Psychiatry Reports·Tanya E FroehlichRichard C Gilman
Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Javier A BravoJohn F Cryan
Nov 23, 2011·Molecular Psychiatry·B FrankeUNKNOWN International Multicentre persistent ADHD CollaboraTion
Dec 16, 2011·Trends in Cognitive Sciences·F Xavier Castellanos, Erika Proal

❮ Previous
Next ❯

Citations

Sep 2, 2020·American Journal of Reproductive Immunology : AJRI·Sharon DavideskoEyal Sheiner
Sep 13, 2020·European Journal of Nutrition·Nonglak BoonchooduangSiriporn C Chattipakorn
Dec 30, 2020·Scientific Reports·Pei-Yin Pan, Sven Bölte
Dec 4, 2020·World Journal of Gastroenterology : WJG·Sivan KedemLior H Katz
Jul 28, 2020·CNS & Neurological Disorders Drug Targets·Qin HuangJian Xia
Jul 10, 2021·Translational Psychiatry·Vanesa RicharteJosep Antoni Ramos-Quiroga

❮ Previous
Next ❯

Related Concepts

Related Feeds

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

European Archives of Psychiatry and Clinical Neuroscience
H J Möller
The Lancet. Gastroenterology & Hepatology
Ashley Cooper
International Journal of High Risk Behaviors & Addiction
Nour-Mohammad Bakhshani
© 2021 Meta ULC. All rights reserved