The role of the heme propionates in heme biochemistry

Journal of Inorganic Biochemistry
Victor Guallar, Brett Olsen

Abstract

There are numerous studies, relying on both experimental and theoretical observations, illustrating the active role of the heme propionates in regulating electron delivery to the iron center as well as biochemical properties of the heme. Evidences for this come from a wide variety of heme containing systems: cytochromes, heme peroxidases, globins, etc. Here, we shortly summarize these studies and revisit previous theoretical calculations (V. Guallar, M.H. Baik, S.J. Lippard, R.A. Friesner, Proc. Natl. Acad. Sci. USA 100 (2003) 6998-7002) where the propionate groups induced the delocalization of the spin density in the cytochrome P450cam putative active species, Compound I. We introduce novel data, obtained by means of mixed quantum mechanics and molecular mechanics methods, indicating a larger electron delocalization into the protein. We also present novel results based on the recent migration of spin density observed by Barrows et al. (T.P. Barrows, T.L. Poulos, Biochemistry 44 (2005) 14062-68) on an ascorbate peroxidase mutant. All this data strongly supports the importance of the propionate groups in tuning the heme electronic properties.

References

Jun 30, 1994·Biochemical and Biophysical Research Communications·T EgawaY Ishimura
Mar 4, 2000·Science·I SchlichtingS G Sligar
Mar 24, 2000·Essays in Biochemistry·I S Isaac, J H Dawson
Apr 11, 2001·Journal of Inorganic Biochemistry·D HarrisL Waskell
Jul 5, 2002·Journal of Molecular Biology·Matthew P JacobsonBarry Honig
Mar 18, 2003·Nature Structural Biology·Katherine H SharpEmma Lloyd Raven
May 29, 2003·Proceedings of the National Academy of Sciences of the United States of America·Victor GuallarRichard A Friesner
Dec 18, 2003·Journal of the American Chemical Society·Sam P de VisserWalter Thiel
Jul 9, 2004·Biochemistry·Tiffany P BarrowsThomas L Poulos
Jul 9, 2004·Journal of the American Chemical Society·Victor Guallar, Richard A Friesner
Mar 9, 2005·Proceedings of the National Academy of Sciences of the United States of America·Victor Guallar, Kenneth W Borrelli
Mar 31, 2005·Annual Review of Physical Chemistry·Richard A Friesner, Victor Guallar
Jun 9, 2005·Chemical Reviews·Ilia G DenisovIlme Schlichting
Sep 30, 2005·Journal of the American Chemical Society·Etienne DeratWalter Thiel

❮ Previous
Next ❯

Citations

May 1, 2008·Journal of the Royal Society, Interface·Victor Guallar, Frank Wallrapp
Apr 29, 2011·Journal of the American Chemical Society·Jeffrey J Warren, James M Mayer
Jan 18, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Henry J NothnagelJuliette T J Lecomte
Jul 20, 2012·Biochemical and Biophysical Research Communications·Brenda J Ramos-Santana, Juan López-Garriga
Jan 10, 2016·Journal of Inorganic Biochemistry·Neval AkbasDabney W Dixon
Apr 20, 2010·Biophysical Chemistry·Victor Guallar, Frank H Wallrapp
Mar 9, 2010·Archives of Biochemistry and Biophysics·Andrea GumieroEmma Lloyd Raven
Oct 25, 2007·Proteins·Eva StjernschantzChris Oostenbrink
Oct 24, 2007·Current Topics in Developmental Biology·Derek B Oien, Jackob Moskovitz
Oct 19, 2006·Organic & Biomolecular Chemistry·Jolanta ZurekAdrian J Mulholland
May 31, 2007·Natural Product Reports·Thomas L Poulos
Mar 24, 2010·Chemical Communications : Chem Comm·Richard LonsdaleAdrian J Mulholland
Sep 22, 2020·The Plant Journal : for Cell and Molecular Biology·Erisa HaradaManabu Horikawa

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.