The Role of the IL-20 Subfamily in Glaucoma

Mediators of Inflammation
Mary K Wirtz, Kate E Keller

Abstract

Glaucoma is a common disease that leads to loss of peripheral vision and, if left untreated, ultimately to blindness. While the exact cause(s) of glaucoma is still unknown, two leading risk factors are age and elevated intraocular pressure. Several studies suggest a possible link between glaucoma and inflammation in humans and animal models. In particular, our lab recently identified a T104M mutation in IL-20 receptor-B (IL-20RB) in primary open angle glaucoma patients from a large pedigree. Several of the interleukin- (IL-) 20 family of cytokines and receptors are expressed in ocular tissues including the trabecular meshwork, optic nerve head, and retinal ganglion cells. The DBA/2J mouse develops high intraocular pressures with age and has characteristic optic nerve defects that make it a useful glaucoma model. IL-24 expression is significantly upregulated in the retina of these mice, while IL-20RA expression in the optic nerve is downregulated following pressure-induced damage. The identification of a mutation in the IL-20RB gene in a glaucoma pedigree and changes in expression levels of IL-20 family members in the DBA/2J mouse suggest that disruption of normal IL-20 signaling in the eye may contribute to degenerative process...Continue Reading

References

Nov 15, 1991·American Journal of Epidemiology·J M TielschA Sommer
Dec 1, 1994·Experimental Eye Research·R C TripathiB J Tripathi
Jan 27, 1999·Progress in Retinal and Eye Research·H A Quigley
Dec 20, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K YamakiS Sakuragi
May 25, 2001·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·M InataniY Honda
Dec 18, 2001·Nature Genetics·Michael G AndersonSimon W M John
Jan 30, 2002·The British Journal of Ophthalmology·Paul J FosterGordon J Johnson
Mar 14, 2002·Journal of Glaucoma·C F Burgoyne, J C Morrison
Jun 1, 2002·Science·David S Aaronson, Curt M Horvath
Oct 31, 2002·The Journal of Biological Chemistry·Changsoo ChangAlexander Zdanov
Dec 12, 2003·Nature Reviews. Immunology·J Wayne Streilein
Sep 15, 2004·American Journal of Ophthalmology·Robert N WeinrebWilliam B Kannel
Dec 22, 2004·Progress in Retinal and Eye Research·John C MorrisonLijun Jia
Jan 27, 2005·Investigative Ophthalmology & Visual Science·J Crawford DownsClaude F Burgoyne
Mar 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael G AndersonSimon W M John
Mar 1, 2006·Investigative Ophthalmology & Visual Science·Denise M InmanDavid J Calkins
Jun 16, 2007·Journal of Glaucoma·Michael V Boland, Harry A Quigley
Oct 8, 2008·Trends in Immunology·Joan Stein-Streilein
Dec 18, 2008·Experimental Eye Research·Kate E KellerTed S Acott
Jun 16, 2009·Journal of Glaucoma·Elaine C Johnson, John C Morrison
May 14, 2010·Investigative Ophthalmology & Visual Science·Uttio Roy ChowdhuryMichael P Fautsch
Jul 2, 2010·Investigative Ophthalmology & Visual Science·John KuchteyRachel W Kuchtey
Sep 25, 2010·Cytokine & Growth Factor Reviews·Ursula Maria Wegenka
Jan 20, 2011·The Journal of Comparative Neurology·Alejandra BoscoMonica L Vetter
Jul 23, 2011·Arquivos brasileiros de oftalmologia·Mauro Toledo LeiteFelipe Andrade Medeiros
Dec 14, 2011·Investigative Ophthalmology & Visual Science·Yasuyuki TakaiAkihiro Ohira
Jan 13, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yu-Hsiang HsuMing-Shi Chang
Jan 21, 2012·Current Opinion in Ophthalmology·W Daniel Stamer, Ted S Acott
Apr 25, 2012·Annual Review of Neuroscience·Robert W NickellsSimon W M John
May 9, 2012·Investigative Ophthalmology & Visual Science·Stuart J McKinnon
Jul 18, 2012·Proceedings of the National Academy of Sciences of the United States of America·Naomi J LogsdonMark R Walter

❮ Previous
Next ❯

Citations

Sep 27, 2016·Progress in Retinal and Eye Research·M Elizabeth FiniW Daniel Stamer
Sep 28, 2018·Journal of Leukocyte Biology·Jun ChenWai Po Chong
May 31, 2018·Molecular Medicine Reports·Hong-Wei WangFeng Gao

❮ Previous
Next ❯

Methods Mentioned

BETA
peptide assay

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Related Papers

Survey of Ophthalmology
R Naskar, E B Dreyer
British Journal of Pharmacology
Rita Rosenthal, Michael Fromm
© 2022 Meta ULC. All rights reserved