PMID: 18407093May 1, 1992Paper

The role of the immunoendocrine interaction via the hypothalamo-pituitary-adrenal axis in autoimmune disease Emphasis on the obese strain chicken model

Trends in Endocrinology and Metabolism : TEM
G WickJ Gruber

Abstract

The key to the molecular basis of the pathogenesis of autoimmune disease (AID) certainly lies in the identification of genes coding for the altered immune response and those responsible for the susceptibility of the target organ to the autoimmune attack. The elucidation of nonessential modulatory factors is, however, also of great importance, because it is via these routes that an effective AID therapy is practical at the present time. Hormones in general, and those affecting the hypothalamo-pituitary-adrenal (HPA) axis in particular, are among the best candidates for more rational new therapeutic approaches. Studies of immune-endocrine communication in animal models with spontaneously occurring organ-specific or systemic autoimmune diseases are ideal for this kind of investigation, since immunologic studies commencing prior to onset of the AID in question can be performed.

References

Nov 1, 1990·Immunology Today·K N TraillG Jürgens
Jan 1, 1990·Autoimmunity·G KroemerG Wick
Jun 1, 1990·Current Opinion in Rheumatology·R L Wilder, E M Sternberg
Feb 1, 1989·Endocrine Reviews·A BatemanS Solomon
Dec 1, 1987·Immunology Letters·G WickK Hála
Jun 1, 1988·Immunology Today·G KroemerG Wick
Jun 21, 1968·Science·R K ColeE Witebsky
Jan 1, 1982·Immunological Reviews·T R Cupps, A S Fauci
Oct 18, 1984·The New England Journal of Medicine·Y Shoenfeld, R S Schwartz
Apr 1, 1985·Immunology Today·J E Blalock, E M Smith
Dec 1, 1983·Immunology Today·H O BesedovskyE Sorkin

❮ Previous
Next ❯

Citations

Oct 1, 1994·Veterinary Immunology and Immunopathology·K W KelleyR Dantzer
Jul 1, 1997·Experimental Gerontology·G Wick, B Grubeck-Loebenstein
Oct 1, 1994·Neuropathology and Applied Neurobiology·T Smith, M L Cuzner
Aug 1, 1994·Journal of Neuroimmunology·M J TehraniG Wick
Jan 1, 1992·International Reviews of Immunology·G WickK Hála
Oct 16, 2004·Journal of Neurosurgery·Ronald J BenvenisteKalmon D Post
Mar 13, 2003·Pflügers Archiv : European journal of physiology·Francisco J Muñoz, Mónica Fuente
Jan 1, 1995·Clinical and Experimental Immunology·J A González-HernándezW A Scherbaum

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.