The role of the insulin-like growth factor-1 system in breast cancer

Molecular Cancer
Panagiotis F ChristopoulosMichael Koutsilieris

Abstract

IGF-1 is a potent mitogen of major importance in the mammary gland. IGF-1 binding to the cognate receptor, IGF-1R, triggers a signaling cascade leading to proliferative and anti-apoptotic events. Although many of the relevant molecular pathways and intracellular cascades remain to be elucidated, a growing body of evidence points to the important role of the IGF-1 system in breast cancer development, progression and metastasis. IGF-1 is a point of convergence for major signaling pathways implicated in breast cancer growth. In this review, we provide an overview and concise update on the function and regulation of IGF-1 as well as the role it plays in breast malignancies.

References

Dec 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·C K OsborneM E Lippman
May 1, 1996·Journal of Endocrinological Investigation·V Papa, A Belfiore
Dec 8, 1998·International Journal of Cancer. Journal International Du Cancer·H YuE P Diamandis
Aug 30, 2000·Nature·C M PerouD Botstein
Sep 21, 2000·Journal of the National Cancer Institute·H Yu, T Rohan
Sep 22, 2001·Endocrine-related Cancer·D Sachdev, D Yee
Dec 26, 2001·Journal of the National Cancer Institute·Y LuM Pollak
Apr 23, 2003·FEBS Letters·Shirley AbramovitchHaim Werner
May 28, 2003·Cancer Letters·Derek LeRoith, Charles T Roberts
Feb 3, 2005·Breast Disease·Francesco FrascaIra D Goldfine
Mar 10, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Bruce D CohenJames D Moyer
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Caroline DiorioJacques Brisson
Jun 7, 2005·Cytokine & Growth Factor Reviews·Adam DenleyBriony E Forbes
Sep 27, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Irit NahorHaim Werner
Jan 3, 2006·Critical Reviews in Oncology/hematology·C GennigensJ P Droz
Nov 26, 2008·Nature Reviews. Cancer·Michael Pollak
Apr 21, 2009·Oncogene·R A JonesR A Moorehead
Jan 28, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicole M Probst-HenschHolger Moch
Feb 11, 2010·Science Signaling·Bita SehatOlle Larsson
Feb 24, 2010·Expert Opinion on Biological Therapy·Antonio Gualberto
Apr 8, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Razelle KurzrockLia Gore
May 18, 2010·The Lancet Oncology·UNKNOWN Endogenous Hormones and Breast Cancer Collaborative GroupAndrew W Roddam
Aug 17, 2010·Cancer Research·Tamara AleksicValentine M Macaulay

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Citations

Aug 1, 2015·International Journal of Molecular Sciences·Bodo C Melnik
Jan 11, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gillian BrowneJane B Lian
Dec 31, 2015·Breast Cancer Research and Treatment·Saki NakagawaHironobu Sasano
Nov 4, 2015·Frontiers in Oncology·Paolo Giovanni VigneriLivia Manzella
Jul 15, 2015·Oxidative Medicine and Cellular Longevity·Patrizia FerroniMario Roselli
Jul 5, 2016·Frontiers in Oncology·Joy ShiHarriet Richardson
Dec 8, 2016·Anais Da Academia Brasileira De Ciências·Danylo R Costa-SilvaBenedito B DA Silva
Jan 25, 2018·Journal of Cellular Biochemistry·Cecilia Rodriguez-MonterrosasEduardo P Salazar
Dec 14, 2017·Journal of Cellular Biochemistry·Cecilia Rodriguez-MonterrosasEduardo Perez Salazar
Jun 26, 2018·Cancer Causes & Control : CCC·Lusine YaghjyanRulla M Tamimi
Jun 19, 2018·Journal of Clinical Gastroenterology·Barbara WlodarczykEwa Malecka-Panas
Jun 29, 2018·The Journal of Clinical Investigation·Sabrina RizzolioLuca Tamagnone
Aug 17, 2018·International Journal of Molecular Sciences·Armando CeveniniEsther Imperlini
Sep 12, 2018·Journal of Cellular Biochemistry·Shao-Ying LiShao-Jun Chen
Sep 15, 2018·Endocrinology·Chifei KangEmily J Gallagher
Mar 28, 2019·Current Medicinal Chemistry·Ennio AvolioAntonino De Lorenzo
Aug 20, 2017·Cancer Causes & Control : CCC·Mark J PowellChristopher C Benz
Nov 23, 2019·Current Drug Targets·Fatemeh ForouzanfarSamira Asgharzade
Jun 10, 2020·Nutrition and Cancer·Zeinab AlboghobeishBahram Rashidkhani
Sep 25, 2019·Scientific Reports·Ramesh ElangoNehad M Alajez
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Morteza MotallebnezhadMehdi Yousefi
Apr 29, 2016·Molecular Medicine Reports·Wojciech KwasniewskiJan Kotarski
Aug 17, 2019·European Review of Aging and Physical Activity : Official Journal of the European Group for Research Into Elderly and Physical Activity·Dora PrakschEszter Szabados

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Methods Mentioned

BETA
glycosylation
nuclear translocation
xenograft
biopsy

Clinical Trials Mentioned

NCT00635245
NCT01536145
NCT00372996
NCT00699491
NCT00684983
NCT00882674
NCT00796107
NCT00954512
NCT01205685
NCT01225172

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