The role of the insulin-like growth factor system in the developing brain

Hormone Research
G A WertherG Butler

Abstract

Insulin-like growth factors (IGFs) play a central role in brain growth and development, with IGF-1, its receptors and binding proteins (IGFBPs) being highly expressed, particularly in the olfactory bulb (OB), representing a local paracrine system. A potential role of IGFBPs in transporting and targeting IGFs to their receptors is supported by the finding that abundant IGFBP-2 is associated with cell surface proteoglycans. An OB organ culture system expressing IGF-1 and IGFBPs represents an in vitro injury model. Although IGF-1 is potently antiapoptotic for neurons and oligodendrocytes, marked gliosis and IGFBP-3 expression are seen, similar to in vivo injury responses, where intraventricular injection of IGF-1 postinjury enhances neuronal survival by blocking apoptosis. In contrast, des (1-3) IGF-1, which has low affinity for IGFBPs, is ineffective, supporting a transport or receptor targeting role for local IGFBPs. We conclude that the IGF system plays a crucial cell survival and growth role in the developing and injured brain and that IGFs have significant therapeutic potential.

Citations

Feb 28, 2003·General and Comparative Endocrinology·G RadaelliB Funkenstein
Dec 28, 1999·Brain Research. Developmental Brain Research·N L BakerG A Werther
Jun 28, 2000·Progress in Neurobiology·A Mackay-Sima, M I Chuahb
Apr 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Christine P DonahueTracey J Shors
Mar 28, 2009·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Tameko KihiraRalph M Garruto
Apr 16, 2014·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Irum NaureenJaleel A Miyan
Feb 27, 2008·Journal of Molecular Neuroscience : MN·Daniel ChesikNadine Wilczak
Mar 20, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sarah A SternCristina M Alberini
Oct 4, 2005·The European Journal of Neuroscience·Richard D McCurdyAlan Mackay-Sim
Jul 18, 2014·Neuron·Vittorio Gallo, Benjamin Deneen
Apr 4, 2015·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Anna KopczakStefan Kloiber
Jul 30, 2014·Frontiers in Pediatrics·Eleonora NapoliCecilia Giulivi
Aug 3, 1999·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·J Isgaard, A Tivesten
Oct 13, 2010·Molecular Psychiatry·T Nickl-Jockschat, T M Michel
Dec 13, 2003·Endocrine Reviews·Stephanie R EdmondsonChristopher J Wraight
Sep 1, 2005·Endocrine Reviews·V C RussoG A Werther
Dec 21, 2000·Neuropathology and Applied Neurobiology·M GiannakopoulouF Stylianopoulou
Apr 19, 2005·Journal of Child Neurology·Raili Riikonen, Ursula Turpeinen
Aug 12, 2006·Journal of Child Neurology·Maria J HenwoodAdda Grimberg
Nov 7, 2002·International Journal of Oral and Maxillofacial Surgery·H Schilephake

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