The role of the kidney in hyperglycemia: a new therapeutic target in type 2 diabetes mellitus.

The Journal of Cardiovascular Nursing
Debbie Hinnen

Abstract

Diabetes is a complex and chronic metabolic disease characterized by hyperglycemia due to defects in the secretion and action of insulin. Diabetes affects more than 8% of the US population. Type 2 diabetes mellitus (T2DM) is the most common form of diabetes and is associated with the development of a number of devastating microvascular complications, including retinopathy, neuropathy, and nephropathy. Diabetes is also a major risk factor for heart disease and stroke. Despite the availability of numerous treatment options for T2DM, glycemic control rates remain poor. Recently, there has been renewed interest in the role that the kidney plays in glucose homeostasis and the potential of the kidney as a therapeutic target in T2DM. This article discusses the role of the kidneys and particularly sodium glucose cotransporter 2 in glucose homeostasis and the potential of inhibiting this transporter as a new treatment option for T2DM. The kidney plays an important role in glucose homeostasis by reabsorbing filtered glucose. In patients with T2DM, glucose reabsorption appears to be increased, potentially contributing to the hyperglycemia associated with this disease. Initial results from clinical trials with a number of sodium glucose co...Continue Reading

References

Jan 1, 1986·Kidney International·B D RossP Silva
May 1, 1987·The Journal of Clinical Investigation·L RossettiR A DeFronzo
Oct 1, 1994·Physiological Reviews·M A Hediger, D B Rhoads
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Feb 1, 1997·Kidney International·F H Epstein
Jan 3, 2001·American Journal of Physiology. Renal Physiology·E M Wright
Feb 24, 2001·Diabetes Care·J E GerichM Stumvoll
Jan 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Christian MeyerJohn E Gerich
Feb 6, 2003·The British Journal of Nutrition·I Stuart Wood, Paul Trayhurn
Nov 25, 2003·Diabetes·J Robinson SingletonEva L Feldman
Aug 10, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sabine Scholl-BürgiJochen H H Ehrich
Dec 30, 2004·Diabetes/metabolism Research and Reviews·Joel R L EhrenkranzJesse Roth
Jan 16, 2007·Journal of Internal Medicine·E M WrightD F Loo
May 2, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·K G M M AlbertiJ Shaw
Jul 28, 2007·Journal of the American Society of Nephrology : JASN·Robert N Foley, Allan J Collins
Feb 8, 2008·The New England Journal of Medicine·Peter GaedeOluf Pedersen
Apr 12, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Janaka Karalliedde, Luigi Gnudi
Jul 9, 2008·Nature Clinical Practice. Endocrinology & Metabolism·Suma DronavalliGeorge L Bakris
Sep 12, 2008·The New England Journal of Medicine·Rury R HolmanH Andrew W Neil
Dec 31, 2008·Diabetes Care·James F ListFred T Fiedorek
Mar 28, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Olivera Marsenic
Apr 10, 2009·Kidney International·George L BakrisErnest M Wright
Oct 27, 2009·Expert Opinion on Therapeutic Patents·William N Washburn
Nov 13, 2009·Diabetes Care·Vivian A Fonseca
Dec 8, 2009·Clinical Journal of the American Society of Nephrology : CJASN·René Santer, Joaquim Calado
Jan 15, 2010·JAMA : the Journal of the American Medical Association·Katherine M FlegalLester R Curtin
May 15, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ele Ferrannini
May 29, 2010·Nature Reviews. Drug Discovery·Edward C Chao, Robert R Henry
Jun 16, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·J E Gerich
Dec 1, 2010·Diabetes·Michael W SchwartzVincenzo Cirulli
Jan 14, 2011·Diabetes Care·UNKNOWN American Diabetes Association

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.