The role of the killer cell immunoglobulin-like receptor (KIR) "missing self" model in unrelated donor HSCT: a meta-analysis

Transplantation Proceedings
S WuX Zhang

Abstract

Some studies have found that donor-recipient killer cell immunoglobulin g-like receptor (KIRs) ligand compatibility or incompatibility influences the prognosis of hematopoietic stem cell transplantation between unrelated individuals, although the conclusions of these studies are controversial. We performed a meta-analysis concerning unrelated donor transplantation with donor-recipient KIRs compatible or incompatible. A higher 5-year overall survival rate (odds ratio [OR] = 1.93, 95% confidence interval [CI] = 1.03 to 3.61, P = .04) was found in KIR-mismatched transplantations; however, no difference was observed in the incidence of grade 2 to 4 acute graft-vs-host disease (OR = 0.94, 95% CI = 0.71 to 1.24, P = .64), 5-year relapse rate (OR = 1.05, CI = 0.75 to 1.47, P = .77), or transplantation/treatment-related mortality (OR = 0.61, CI = 0.15 to 2.51, P = .50). Our meta-analysis confirmed that incompatibility in KIR ligands favors 5-year overall survival rate but has no effect on the incidence of grade 2 to 4 acute graft-vs-host disease, relapse, or transplantation/treatment-related mortality.

References

Jan 16, 1998·Immunity·M UhrbergP Parham
Jul 26, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sherif S FaragUNKNOWN KIR Study Group, Center for International Blood and Marrow Transplantation Research
Aug 19, 2006·Seminars in Cancer Biology·Loredana RuggeriAndrea Velardi
Feb 24, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yasuo MorishimaUNKNOWN Japan Marrow Donor Program
Oct 30, 2007·Blood Cells, Molecules & Diseases·Loredana RuggeriAndrea Velardi
Dec 27, 2007·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Toshio YabeUNKNOWN Japan Marrow Donor Program
Aug 5, 2008·Current Opinion in Immunology·Andrea Velardi
Nov 30, 2010·Bone Marrow Transplantation·L BühlmannM Stern
Dec 14, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Daniel WeisdorfJeffrey Miller
Aug 31, 2012·The New England Journal of Medicine·Jeffrey M VenstromKatharine C Hsu

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Citations

Sep 30, 2016·World Journal of Transplantation·Hisham A EdinurNor F Che Mat
Nov 7, 2017·Expert Opinion on Biological Therapy·Katalin Balassa, Vanderson Rocha

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