The role of the left anterior temporal lobe in exception word reading: reconciling patient and neuroimaging findings

NeuroImage
Maximiliano A WilsonSimona Maria Brambati

Abstract

Semantic dementia (SD) is a neurodegenerative disease that occurs following the atrophy of the anterior temporal lobes (ATLs). It is characterised by the degradation of semantic knowledge and difficulties in reading exception words (surface dyslexia). This disease has highlighted the role of the ATLs in the process of exception word reading. However, imaging studies in healthy subjects have failed to detect activation of the ATLs during exception word reading. The aim of the present study was to test whether the functional brain regions that mediate exception word reading in normal readers overlap those brain regions atrophied in SD. In Study One, we map the brain regions of grey matter atrophy in AF, a patient with mild SD and surface dyslexia profile. In Study Two, we map the activation pattern associated with exception word compared to pseudoword reading in young, healthy participants using fMRI. The results revealed areas of significant activation in healthy subjects engaged in the exception word reading task in the left anterior middle temporal gyrus, in a region observed to be atrophic in the patient AF. These results reconcile neuropsychological and functional imaging data, revealing the critical role of the left ATL in ...Continue Reading

References

Dec 1, 1992·Neuropsychologia·K Patterson, J R Hodges
Dec 1, 1992·Brain : a Journal of Neurology·J R HodgesE Funnell
Oct 1, 1989·Psychological Review·M S Seidenberg, J L McClelland
Jul 1, 1973·Journal of Psycholinguistic Research·J C Marshall, F Newcombe
Sep 19, 1996·Nature·R VandenbergheR S Frackowiak
Apr 13, 1999·Neuropsychologia·D PeraniF Fazio
Sep 25, 1999·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·R Peereman, A Content
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Feb 24, 2001·Psychological Review·M ColtheartJ Ziegler
Feb 19, 2002·NeuroImage·J T DevlinC J Price
Apr 2, 2003·NeuroImage·Andrea MechelliKarl J Friston
Apr 5, 2003·Journal of Cognitive Neuroscience·Andrea MechelliCathy J Price
May 2, 2003·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Kenneth I Forster, Jonathan C Forster
May 14, 2003·Neuron·Guillaume ThierryCathy Price
Jun 20, 2003·NeuroImage·R DeichmannR Turner
Oct 11, 2003·Urology·Penny S Brucker, David Cella
Feb 27, 2004·Brain : a Journal of Neurology·J S SnowdenD Neary
Mar 3, 2004·Annals of Neurology·Maria Luisa Gorno-TempiniBruce L Miller
May 4, 2004·Brain and Language·P BrightL K Tyler
Oct 28, 2004·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Maria Luisa Gorno-TempiniBruce Lars Miller
Jan 12, 2005·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Wouter DuyckMarc Brysbaert
Jan 12, 2005·Behavior Research Methods, Instruments, & Computers : a Journal of the Psychonomic Society, Inc·Boris NewLudovic Ferrand
Jun 1, 2005·NeuroImage·J R BinderE Liebenthal
Jun 16, 2005·NeuroImage·John Ashburner, Karl J Friston
Nov 5, 2005·Journal of Cognitive Neuroscience·Andrea MechelliCathy J Price
Feb 24, 2006·Journal of Cognitive Neuroscience·Karalyn PattersonTimothy T Rogers
Jul 4, 2006·Brain : a Journal of Neurology·Elizabeth Jefferies, Matthew A Lambon Ralph
May 16, 2007·Psychological Review·Anna M WoollamsKaralyn Patterson
Sep 1, 2007·NeuroImage·John Ashburner
Nov 21, 2007·Nature Reviews. Neuroscience·Karalyn PattersonTimothy T Rogers
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gorana PobricMatthew A Lambon Ralph
Aug 6, 2008·Cerebral Cortex·Matthew A Lambon RalphElizabeth Jefferies
Nov 22, 2008·Brain : a Journal of Neurology·Stephen M WilsonMaria Luisa Gorno-Tempini
May 12, 2009·Neuropsychologia·S M BrambatiM L Gorno-Tempini
Jun 10, 2009·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·Christopher R ButlerMaria-Luisa Gorno-Tempini
Jul 6, 2010·NeuroImage·Simona Maria BrambatiSven Joubert

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Citations

Dec 11, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Anna M Woollams
Jul 1, 2015·Proceedings of the National Academy of Sciences of the United States of America·Paul HoffmanAnna M Woollams
Jun 25, 2015·NeuroImage. Clinical·Simona Maria BrambatiMaria Luisa Gorno-Tempini
Jul 9, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Richard J BinneyMaria Luisa Gorno-Tempini
Sep 15, 2016·Frontiers in Psychology·Georges ChedidSimona M Brambati
Oct 27, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jean-Sebastien ProvostMaximiliano A Wilson
Aug 4, 2018·Brain Structure & Function·Anna M WoollamsMatthew A Lambon Ralph
Aug 14, 2020·Brain : a Journal of Neurology·Valentina BorghesaniSrikantan S Nagarajan
Apr 30, 2019·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Louis-Olivier BouchardSimon Duchesne
Apr 21, 2017·Frontiers in Psychology·Marilyne JoyalMaximiliano A Wilson
Oct 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Florence BouhaliLaurent Cohen
Feb 23, 2020·NeuroImage·Florence BouhaliLaurent Cohen

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