The role of the local anaesthetic properties of beta-adrenoceptor blocking agents in antagonizing CaCl2-induced arrhythmias in the rat

British Journal of Pharmacology
S EvangelistaA Meli

Abstract

1 Eight beta-adrenoceptor blocking agents were compared for their ability to antagonize arrhythmias induced by bolus injections of CaCl2 in rats. 2 Only those beta-blockers possessing local anaesthetic properties were effective in antagonizing this type of arrhythmia and there was a highly significant correlation between antiarrhythmic and local anaesthetic properties. 3 Effects on adrenoceptors seem to play only a minor role in the genesis of this type of arrhythmia.

References

Jun 1, 1969·British Journal of Pharmacology·A N DohadwallaE M Vaughan Williams
Mar 1, 1981·The Journal of Pharmacy and Pharmacology·G GrimaldiA Meli
Nov 1, 1953·Circulation Research·M R MALINOWB MALAMUD
Jun 1, 1956·British Journal of Pharmacology and Chemotherapy·C BIANCHI

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Citations

Sep 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·F Chollet-DebordP Duchene-Marullaz
Oct 1, 1992·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Y HayashiI Yoshiya
Jun 1, 1984·Journal of Autonomic Pharmacology·F J MiñanoJ A Duran
Jan 1, 1996·Journal of Toxicology. Clinical Toxicology·W WananukulP R Pentel

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