PMID: 6971859Feb 1, 1981Paper

The role of the maturation stage of thymocytes on the phytohemagglutinin and concanavalin A responses in thymocyte and lymph node lymphocyte cocultures in guinea pig. Effects of pretreatment of thymocytes with thymosin or levamisole

Immunopharmacology
E Soppi

Abstract

Guinea pig thymocytes (TH) and lymph node lymphocytes (LNL) synergized optimally in both phytohemagglutinin (PHA) and concanavalin (Con A) responses in mixtures containing 0.3 x 10(6) TH and 0.2 x 10(6) LNL. Using discontinuous albumin gradient centrifugation thymocytes were separated into two subpopulations (F4 and F6) at different stages of maturation. Immature, PHA and Con A unresponsive F6 thymocytes synergized significantly only in the PHA response. More mature, PHA and Con A responsive F4 thymocytes cooperated well in the Con A response, but only a small synergy was observed in the PHA response. Pretreatment of the unfractionated thymocytes with the low concentration (0.05 microgram/ml) of thymosin decreased significantly their capacity to interact with LNL in both PHA and Con A responses. Preincubation of F4 thymocytes with the high concentration (200 microgram/ml) of thymosin increased the synergy in PHA response. All other combinations with thymosin or levamisole and thymocytes were ineffective on the mitogenic responses in the TH and LNL cocultures. Altogether, the results how that the thymocyte populations that induce synergy in PHA, or in (PHA and) Con A responses represent the two subpopulations of thymocytes with ...Continue Reading

References

Jul 1, 1977·European Journal of Immunology·J A Frelinger
Mar 15, 1979·Cellular Immunology·P W WrightI D Bernstein
Feb 28, 1975·Annals of the New York Academy of Sciences·G H CohenA L Goldstein
Aug 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·J L TouraineR A Good
Jan 1, 1979·Developmental and Comparative Immunology·E SoppiO Ruuskanen
Dec 1, 1975·The Journal of Experimental Medicine·P F PiguetP Vassalli
Aug 1, 1976·The Journal of Experimental Medicine·J J Cohen, S S Fairchild
Feb 1, 1974·European Journal of Immunology·P Häyry, L C Andersson
Feb 1, 1974·Cellular Immunology·H Jacobsson, H Blomgren

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