The role of the medial caudate nucleus, but not the hippocampus, in a matching-to sample task for a motor response

The European Journal of Neuroscience
R P Kesner, Paul E Gilbert

Abstract

A delayed-match-to-sample task was used to assess memory for motor responses in rats with control, hippocampus, or medial caudate nucleus (MCN) lesions. All testing was conducted on a cheeseboard maze in complete darkness using an infrared camera. A start box was positioned in the centre of the maze facing a randomly determined direction on each trial. On the sample phase, a phosphorescent object was randomly positioned to cover a baited food well in one of five equally spaced positions around the circumference of the maze forming a 180-degree arc 60 cm from the box. The rat had to displace the object to receive food and return to the start box. The box was then rotated to face a different direction. An identical baited phosphorescent object was placed in the same position relative to the start box. A second identical object was positioned to cover a different unbaited well. On the choice phase, the rat must remember the motor response made on the sample phase and make the same motor response on the choice phase to receive a reward. Hippocampus lesioned and control rats improved as a function of increased angle separation used to separate the correct object from the foil (45, 90, 135, and 180 degrees) and matched the performanc...Continue Reading

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Citations

Feb 11, 2011·Journal of Neurophysiology·Terra D BarnesAnn M Graybiel
Feb 5, 2014·Social Cognitive and Affective Neuroscience·Jacqueline A ClaussJennifer Urbano Blackford
Jan 26, 2013·Behavioural Brain Research·Raymond P Kesner
Oct 10, 2012·Neuroscience and Biobehavioral Reviews·Michael R Hunsaker, Raymond P Kesner
Jun 28, 2011·Neurobiology of Learning and Memory·Bryan D DevanRobert J McDonald
Jul 29, 2010·The International Journal of Neuropsychopharmacology·Mark J MillanJay S Schneider
Dec 3, 2014·Neuroscience and Biobehavioral Reviews·Raymond P Kesner, Edmund T Rolls
Jun 20, 2006·Progress in Neurobiology·Edmund T Rolls, Raymond P Kesner

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