The role of the melatoninergic system in epilepsy and comorbid psychiatric disorders

Brain Research Bulletin
Jana TchekalarovaRichard Teke Ngomba

Abstract

There is emerging evidence of the beneficial role of the melatonin system in a wide range of psychiatric and neurologic disorders, including anxiety, depression, and epilepsy. Although melatoninergic drugs have chronobiotic and antioxidant properties that positively influence circadian rhythm desynchronization and neuroprotection in neurodegenerative disorders, studies examining the use of melatonin for epilepsy's comorbid psychiatric and neurological symptomatology are still limited. Preclinical and clinical findings on the beneficial effects of the melatonin system on anxiety, depression, and epilepsy suggest that melatoninergic compounds might be effective in treating comorbid behavioral complications in epilepsy beyond regulation of a disturbed sleep-wake cycle.

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Citations

Mar 27, 2016·Behavioural Brain Research·Paula MosińskaPiotr Wlaź
Nov 22, 2016·Expert Review of Neurotherapeutics·Feng Liu, Xuefeng Wang
Jul 11, 2018·International Journal of Molecular Sciences·Slavianka MoyanovaJane Tchekalarova
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Dec 2, 2020·Life Sciences·Enes AkyuzYam Nath Paudel
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Oct 30, 2021·Journal of Neuroscience Research·Enes AkyuzYam Nath Paudel
Jan 12, 2021·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Jana TchekalarovaPavlina Andreeva-Gateva

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