PMID: 5905241Feb 1, 1966

The role of the microbial flora in uremia. II. Uremic colitis, cardiovascular lesions, and biochemical observations

The Journal of Experimental Medicine
D CarterW F Burns


Uremic colitis of varying severity occurred in the majority of conventionalized rats dying after removal of both kidneys, but was not found in uremic conventionalized and germfree rats sacrificed preterminally, or in germfree and limited-flora rats dying from uremia, or in any of the controls. The lesions were restricted to the cecum and their incidence and severity paralleled a shorter duration of survival. Cardiovascular damage including focal myocardial necrosis and calcification and patchy aortic and coronary calcification were observed in uremic rats regardless of their microbial status. These lesions had a higher incidence, developed more rapidly, and were more severe in the germfree and limited-flora rats than in the conventionalized animals. The presence or severity of the lesions, however, did not correlate with survival time of rats dying from uremia or with total plasma calcium and inorganic phosphorus levels of individual animals. Generalized necrotizing arteritis was not observed. Wound healing was poor in all uremic rats regardless of microbial status. Focal infection was noted in a few conventionalized rats dying from uremia, did not correlate with survival time, and was absent in all other groups. Comparison of ...Continue Reading


May 1, 1963·Archives of Pathology·J CHURG
Nov 1, 1963·Proceedings of the Society for Experimental Biology and Medicine·P F SALISBURY, A A POMERANZ
Feb 1, 1965·The Journal of Experimental Medicine·G LINDSTEDTB E GUSTAFSSON
Apr 1, 1965·Clinica Chimica Acta; International Journal of Clinical Chemistry·B KRAMERD SELIGSON


Oct 1, 1978·Kidney International·J D Kopple
Jan 1, 1983·Clinical and Experimental Dialysis and Apheresis·H InamotoA Osawa
May 1, 1989·Veterinary Pathology·J Kaspareit-RittinghausenC Messow
Dec 6, 2016·Cell Host & Microbe·A Sloan DevlinMichael A Fischbach

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