The role of the microbiome in nonhealing diabetic wounds

Annals of the New York Academy of Sciences
Lindsay R Kalan, Meghan B Brennan

Abstract

Wound healing is a highly coordinated and complex process, and there can be devastating consequences if it is interrupted. It is believed that, in combination with host factors, microorganisms in a wound bed can not only impair wound healing but can lead to stalled, chronic wounds. It is hypothesized that the wound microbiota persists in chronic wounds as a biofilm, recalcitrant to antibiotic and mechanical intervention. Cultivation-based methods are the gold standard for identification of pathogens residing in wounds. However, these methods are biased against fastidious organisms, and do not capture the full extent of microbial diversity in chronic wounds. Thus, the link between specific microbes and impaired healing remains tenuous. This is partially because local infection and, more specifically, the formation of a biofilm, is difficult to diagnose. This has led to research efforts aimed at understanding if biofilm formation delays healing and leads to persistent and chronic infection. Circumventing challenges associated with culture-based estimations, advances in high-throughput sequencing analysis has revealed that chronic wounds are host to complex, diverse microbiomes comprising multiple species of bacteria and fungi. He...Continue Reading

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Citations

Jul 28, 2019·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Shinsuke AkitaNobuyuki Mitsukawa
Nov 15, 2019·Chinese Medical Journal·Di WeiMin Zhang
Jul 15, 2020·Scientific Reports·Lisa KarnerPeter Dungel
Aug 9, 2020·International Journal of Nanomedicine·Piotr OrlowskiMalgorzata Krzyzowska
Jun 20, 2020·PLoS Pathogens·Craig D TiptonCaleb D Phillips
Apr 23, 2020·Advances in Wound Care·Carlos Poblete JaraEliana Pereira de Araújo
Dec 4, 2020·Emerging Topics in Life Sciences·Joanna Shepherd
Jun 25, 2020·Current Drug Targets·Hongmin SunDavid W Anderson
Nov 17, 2020·Biomedical Engineering Letters·Petro MyronovMaksym Pogorielov
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May 18, 2021·Revista Clínica Espanõla·T Requena, M Velasco
Sep 18, 2021·Scientific Reports·Catherine Dunyach-RemyAnthony Gélis

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