The role of the MTA family and their encoded proteins in human cancers: molecular functions and clinical implications.

Clinical & Experimental Metastasis
Yasushi Toh, Garth L Nicolson

Abstract

MTA (metastasis-associated gene) is a newly discovered family of cancer progression-related genes and their encoded products. MTA1, the first gene found in this family, has been repeatedly reported to be overexpressed along with its protein product MTA1 in a wide range of human cancers. In addition, the expression of MTA1/MTA1 correlates with the clinicopathological properties (malignant properties) of human cancers. MTA proteins are transcriptional co-repressors that function in histone deacetylation and are involved in the NuRD complex, which contains nucleosome remodeling and histone deacetylating molecules. MTA1 expression correlates with tumor formation in the mammary gland. In addition, MTA1 converts breast cancer cells to a more aggressive phenotype by repression of the estrogen receptor (ER) alpha trans-activation function through deacetylation of the chromatin in the ER-responsive element of ER-responsive genes. Furthermore, MTA1 plays an essential role in c-MYC-mediated cell transformation. Another member of this family, MTA3, is induced by estrogen and represses the expression of the transcriptional repressor Snail, a master regulator of "epithelial to mesenchymal transitions", resulting in the expression of the cell...Continue Reading

References

Aug 22, 1997·International Journal of Cancer. Journal International Du Cancer·Y TohK Sugimachi
Apr 17, 1999·British Journal of Cancer·Y TohK Sugimachi
Nov 2, 2001·Cancer Letters·H SasakiY Fujii
Jan 24, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Hidefumi SasakiYoshitaka Fujii
Nov 13, 2003·Seminars in Oncology·Rakesh KumarRozita Bagheri-Yarmand
Jan 15, 2004·Cancer Immunology, Immunotherapy : CII·Geng LiRobert C Rees
Feb 12, 2004·Cancer Research·Matthias D HoferMark A Rubin
Mar 17, 2004·Biochimica Et Biophysica Acta·Nathan J BowenPaul A Wade
Apr 20, 2004·International Journal of Cancer. Journal International Du Cancer·Yasushi TohGarth L Nicolson
Jun 1, 2004·The Journal of Biological Chemistry·Sandip K MishraRakesh Kumar
Jul 16, 2004·Molecular and Cellular Biology·Amjad H TalukderRakesh Kumar
Sep 11, 2004·Molecular Endocrinology·Naoyuki FujitaPaul A Wade
Jun 28, 2005·FEBS Letters·Yuko AramakiSoichi Takiguchi
Jul 8, 2005·Cancer Immunology, Immunotherapy : CII·Deepak P AssudaniSelman A Ali
Sep 21, 2005·Proceedings of the National Academy of Sciences of the United States of America·Xiao-Yong ZhangSteven B McMahon
Mar 16, 2006·The Journal of Clinical Endocrinology and Metabolism·Irvin M ModlinManish C Champaneria
Apr 18, 2006·Proceedings of the National Academy of Sciences of the United States of America·Anupama E GururajRakesh Kumar
Jun 24, 2006·Annals of Surgery·Irvin M ModlinRobert L Camp
Jun 30, 2006·The Journal of Biological Chemistry·Rajesh R SinghRakesh Kumar

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Citations

Jan 30, 2010·Nature·Lena Ho, Gerald R Crabtree
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Da-Qiang LiRakesh Kumar
Oct 20, 2009·The Journal of Biological Chemistry·Da-Qiang LiRakesh Kumar
Aug 13, 2010·The Journal of Biological Chemistry·Suresh B PakalaRakesh Kumar
Feb 4, 2010·Cancer Research·Yiwei LiFazlul H Sarkar
Oct 11, 2013·Diagnostic Pathology·Shangen ZhengGuoqiang Zhao
Jan 5, 2013·Cell & Bioscience·Meng WuJiemin Wong
Sep 9, 2010·PLoS Genetics·Tamar GeigerMatthias Mann
Oct 12, 2010·Interactive Cardiovascular and Thoracic Surgery·Yang YuHua Zhang
Nov 30, 2011·Epigenomics·Godelieve Smeenk, Haico van Attikum
Mar 31, 2011·World Journal of Gastroenterology : WJG·Bin DuXu-Long Zhou
Aug 18, 2010·International Journal of Biological Sciences·Yi-Hsuan HsiaoYan-gao Man
Oct 25, 2014·Cancer Metastasis Reviews·Zhifeng NingHao Zhang
Oct 17, 2014·Cancer Metastasis Reviews·Ansgar BrüningIoannis Mylonas
Oct 16, 2014·Cancer Metastasis Reviews·Yasushi Toh, Garth L Nicolson
Nov 2, 2014·Cancer Metastasis Reviews·Yasushi Toh, Garth L Nicolson
Oct 19, 2014·Cancer Metastasis Reviews·Soo Hyung RyuYoung-Hwa Chung
Nov 16, 2014·Cancer Metastasis Reviews·Jian LiuHaili Qian
Mar 4, 2014·Biochemical and Biophysical Research Communications·Chao-Juan ZhuWei Li
Dec 3, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Heying ChuGuojun Zhang
Oct 22, 2014·Cancer Metastasis Reviews·Anait S LevensonXu Zhang
Oct 16, 2014·Cancer Metastasis Reviews·Sung Sun Kim, Yong-Koo Park
Nov 7, 2014·Cancer Metastasis Reviews·Ekjot KaurShilpee Dutt
Oct 30, 2014·Cancer Metastasis Reviews·Christopher J MillardJohn W R Schwabe
Oct 22, 2014·Cancer Metastasis Reviews·Yun Zhang, Xiao-Fan Wang
Dec 23, 2009·The Journal of Biological Chemistry·Ming LiBharat Ramratnam
Mar 27, 2013·General Thoracic and Cardiovascular Surgery·Yasushi TohManabu Yamamoto
May 31, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiao-yun MaoFeng Jin
Jul 27, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan WangEnhua Wang
Feb 2, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Seda Tuncay CagataySreeparna Banerjee
Feb 22, 2011·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yumei RaoGang Chen
Apr 18, 2013·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yu-Mei RaoHui-Rong Shi
Mar 27, 2015·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·Sharareh Siamakpour-ReihaniMark W Dewhirst
Jan 20, 2015·Expert Review of Molecular Diagnostics·Cecilia LindskogPatrick Micke

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