The role of the myofibroblast in tumor stroma remodeling.

Cell Adhesion & Migration
Marcela OtrantoAlexis Desmoulière

Abstract

Since its first description in wound granulation tissue, the myofibroblast has been recognized to be a key actor in the epithelial-mesenchymal cross-talk that plays a crucial role in many physiological and pathological situations, such as regulation of prostate development, ventilation-perfusion in lung alveoli or organ fibrosis. The presence of myofibroblasts in the stroma reaction to epithelial tumors is well established and many data are accumulating which suggest that the stroma compartment is an active participant in tumor onset and/or evolution. In this review we summarize the evidence in favor of this concept, the main mechanisms that regulate myofibroblast differentiation and function, as well as the biophysical and biochemical factors possibly involved in epithelial-stroma interactions, using liver carcinoma as main model, in view of achieving a better understanding of tumor progression mechanisms and of tools directed toward stroma as eventual therapeutic target.

References

Apr 1, 1992·Cell and Tissue Research·J E FergusonM W Ferguson
Jan 1, 1989·The Journal of Investigative Dermatology·B CoulombL Dubertret
Dec 1, 1987·The Journal of Cell Biology·U HeineM B Sporn
May 1, 1994·Differentiation; Research in Biological Diversity·J M EstesG Gabbiani
Feb 1, 1994·The Journal of Cell Biology·F Grinnell
Nov 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H LeylandR C Benyon
Apr 1, 1997·British Journal of Urology·S W HaywardG R Cunha
Sep 12, 1998·The Journal of Investigative Dermatology. Symposium Proceedings·B Le VarletF Bonté
Apr 2, 1999·Science·M F PittengerD R Marshak
Aug 19, 1999·The Journal of Pathology·B Le BailJ Rosenbaum
Nov 26, 1999·American Journal of Respiratory Cell and Molecular Biology·H Y Zhang, S H Phan
Jun 8, 2001·Journal of Hepatology·L DubuissonA Desmoulière
Jun 9, 2001·Experimental Biology and Medicine·J J MinguellP Conget
Sep 5, 2001·Nature Cell Biology·J G TomaF D Miller
Sep 13, 2001·Molecular Biology of the Cell·B HinzC Chaponnier
Jan 5, 2002·International Journal of Cancer. Journal International Du Cancer·Arnaud MonvoisinJean Rosenbaum
May 4, 2002·Nature Reviews. Molecular Cell Biology·James J TomasekRobert A Brown
Jun 6, 2002·Journal of Cellular Biochemistry. Supplement·Kathyjo A JacksonMargaret A Goodell
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
Dec 17, 2002·Journal of Cell Science·Justin P AnnesDaniel B Rifkin
Dec 20, 2002·Nature·Lisa M Coussens, Zena Werb
Apr 17, 2003·The Journal of Surgical Research·Mark A CarlsonJon S Thompson
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthias SchmidtSabrina Mattoli
Jul 5, 2003·Physiological Reviews·Sabine Werner, Richard Grose
Sep 13, 2003·World Journal of Gastroenterology : WJG·Kai LiuBing-Jun Lei
Nov 19, 2003·Mechanisms of Development·David Shook, Ray Keller

❮ Previous
Next ❯

Citations

Apr 6, 2013·Biomedical Microdevices·Peter DelNeroClaudia Fischbach
May 7, 2013·Annual Review of Biomedical Engineering·David W InfangerClaudia Fischbach
Nov 15, 2012·Oxidative Medicine and Cellular Longevity·Natalie SampsonChristoph Zenzmaier
Jan 11, 2014·World Journal of Gastroenterology : WJG·Sébastien LepreuxAlexis Desmoulière
Apr 5, 2014·BioMed Research International·Natalie SampsonChristoph Zenzmaier
Sep 18, 2013·Antioxidants & Redox Signaling·Johannes A Eble, Flávia Figueiredo de Rezende
Jun 26, 2014·BioMed Research International·Catarina Roma-RodriguesPedro Viana Baptista
Dec 4, 2013·Advanced Drug Delivery Reviews·Maria HåkansonMirren Charnley
Sep 7, 2013·Molecular Cancer Research : MCR·Holly E BarkerJanine T Erler
Feb 20, 2015·Journal of Functional Biomaterials·Isaac M Adjei, Sharma Blanka
Sep 16, 2015·International Journal of Cancer. Journal International Du Cancer·Mitsuru YokotaAtsushi Ochiai
Jan 6, 2016·Journal of Clinical Medicine·Anusha H TennakoonJyoji Yamate
Jul 23, 2013·Connective Tissue Research·Barry StarcherCoty Ho
Mar 26, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Henna M KarvonenRiitta L Kaarteenaho
Feb 11, 2016·International Journal of Molecular Sciences·Chiara CiardielloDolores Di Vizio
Jun 23, 2015·Journal of Cellular Physiology·Jon M CarthyAristidis Moustakas
Dec 3, 2014·Cellular Signalling·Marina Y ZemskovaAndrew S Kraft
Oct 7, 2015·Methods : a Companion to Methods in Enzymology·Marta TelloJacky G Goetz
Sep 22, 2012·The Journal of Pathology·Franco KlingbergEric S White
Aug 13, 2013·Periodontology 2000·Boris Hinz
Jan 17, 2016·International Journal of Cancer. Journal International Du Cancer·Joannie M AllaireNathalie Perreault
May 13, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sankalpa ChakrabortyAlo Nag
Mar 13, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhi-Feng MiaoHui-Mian Xu
Jul 23, 2015·Biophysical Journal·Joshua S McLane, Lee A Ligon
Mar 17, 2015·Urologic Oncology·Unai SilvánJuan Aréchaga
Mar 22, 2015·The American Journal of Pathology·Becky K BrissonSusan W Volk
Aug 7, 2012·Cell Adhesion & Migration·Jacky G Goetz
Oct 26, 2014·Annals of Biomedical Engineering·Jenna L Balestrini, Laura E Niklason
Feb 27, 2013·The American Journal of Pathology·Jung S Byun, Kevin Gardner
Jul 30, 2014·Frontiers in Pharmacology·Sonali Kapse-MistryMayur Yergeri
Jul 17, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Jay Gopal RayAmit Chattopadhyay

❮ Previous
Next ❯

Methods Mentioned

BETA
atomic force microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Arteriosclerosis, Thrombosis, and Vascular Biology
Matteo CoenMarie-Luce Bochaton-Piallat
Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society
Vincent SarrazyAlexis Desmoulière
The American Journal of Pathology
Boris HinzGiulio Gabbiani
Expert Reviews in Molecular Medicine
Kornelia KisJames S Hagood
© 2021 Meta ULC. All rights reserved