Sep 1, 1993

The role of the neurotransmitters acetylcholine and noradrenaline in the pathogenesis of stress ulcers

Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology
J GatónA Velasco


1. Adrenergic and cholinergic mechanisms seem to be involved in the pathogenesis of stress ulcers. 2. In this study, gastric ulcers were induced in rats by immobilization and cold. Prior intraperitoneal administration of both anticholinergic (atropine) as well as alpha-blocking medication (phenoxybenzamine) produced a very significant decrease in stress ulcers. 3. Additionally, using the technique of continuous intravenous perfusion in rats, acetylcholine was shown to have a gastric ulcerogenic effect, in contrast to noradrenaline. 4. It is concluded that acetylcholine is the peripheral mediator in stress ulcers, while noradrenaline intervenes at the encephalic level in stress ulcer pathogenesis.

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Mentioned in this Paper

Pathogenic Aspects
Gastric Ulcer
Atropinum, atropine
Norepinephrine, (+, -)-Isomer
Anticholinergic [EPC]
Norepinephrine Measurement

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