The role of the NO pathway in the control of cardiac function

Journal of Cardiac Failure
T W SmithR A Kelly

Abstract

Nitric oxide (NO) acts as an autocrine- and paracrine-acting signaling autacoid that, among other functions, has been shown to regulate cardiac contractile responsiveness to beta-adrenergic and muscarinic cholinergic agonists. Nitric oxide (NO) is formed by the oxidation of one of two equivalent guanidino nitrogens in L-arginine by O2 to form NO and L-citrulline. This reaction is catalyzed by a family of enzymes termed NO synthases. Three distinct isoforms of NOS have been identified, each the product of a separate gene. Cellular constituents of cardiac muscle, including ventricular myocytes as well as microvascular endothelial cells, have been shown to express the "endothelial constitutive" isoform of NO synthase (ecNOS or NOS3) in vivo, and both cell types also express the NO synthase isoform induced by specific inflammatory cytokines (iNOS or NOS2) in vivo and in vitro. While NO-dependent intracellular signalling in cardiac myocytes clearly involves the activation of guanylate cyclase and downstream signalling by cGMP, there is accumulating evidence that non-cGMP-dependent regulatory signalling events are also initiated by NO. In addition, decreased contractile responsiveness of cardiac myocytes to beta-adrenergic agonists, ...Continue Reading

References

Nov 23, 1995·Nature·M A Marchionni
Jan 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J L BalligandT Michel
Feb 26, 1993·Biochemical and Biophysical Research Communications·Y NunokawaS Tanaka
Jul 1, 1993·Circulation Research·I KuroseD N Granger
Apr 15, 1994·The Journal of Physiology·X HanW R Giles
Sep 23, 1994·Cell·H H Schmidt, U Walter
Jun 30, 1993·Biochemical and Biophysical Research Communications·T MalinskiP Tomboulian
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G McClellanS Winegrad
May 1, 1993·Proceedings of the Society for Experimental Biology and Medicine·E R WernerH Wachter
May 1, 1993·Trends in Cardiovascular Medicine·A M Shah, M J Lewis

❮ Previous
Next ❯

Citations

Jun 14, 2002·International Journal for Parasitology·Madhulika ChandraJamshid Shirani
Jul 10, 2010·Saudi Journal of Gastroenterology : Official Journal of the Saudi Gastroenterology Association·Waleed K Al-Hamoudi
Dec 4, 2013·Antioxidants & Redox Signaling·Jennifer K BendallMark J Crabtree
Mar 10, 2015·Circulation Journal : Official Journal of the Japanese Circulation Society·Euy-Myoung Jeong, Samuel C Dudley
Sep 1, 2005·European Journal of Clinical Investigation·D PevniG Uretzky
Apr 24, 2012·Liver International : Official Journal of the International Association for the Study of the Liver·Leila Moezi, Ahmad R Dehpour
Sep 8, 2001·American Journal of Physiology. Cell Physiology·J H NascimentoN Peineau
Jun 5, 2003·Journal of Hypertension·Giulio SelvetellaGiuseppe Lembo
Mar 8, 2006·World Journal of Gastroenterology : WJG·HongQun LiuSamuel S Lee
Oct 24, 2000·Journal of Chromatography. B, Biomedical Sciences and Applications·E M SiaghyP M Mertes
Sep 28, 2000·Cell Calcium·N Kraus-Friedmann

❮ Previous
Next ❯

Related Concepts

Related Papers

Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva
A CruzF J Padillo
Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society
Edward J F Danson
European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery
D PevniR Mohr
Mammalian Genome : Official Journal of the International Mammalian Genome Society
A Y DengM T Bihoreau
© 2021 Meta ULC. All rights reserved