The role of the non-homologous end-joining pathway in lymphocyte development

Immunological Reviews
Sean RooneyFrederick W Alt

Abstract

One of the most toxic insults a cell can incur is a disruption of its linear DNA in the form of a double-strand break (DSB). Left unrepaired, or repaired improperly, these lesions can result in cell death or neoplastic transformation. Despite these dangers, lymphoid cells purposely introduce DSBs into their genome to maximize the diversity and effector functions of their antigen receptor genes. While the generation of breaks requires distinct lymphoid-specific factors, their resolution requires various ubiquitously expressed DNA-repair proteins, known collectively as the non-homologous end-joining pathway. In this review, we discuss the factors that constitute this pathway as well as the evidence of their involvement in two lymphoid-specific DNA recombination events.

References

May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·T Honjo, T Kataoka
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·A DvirW S Dynan
Jan 1, 1992·Current Topics in Microbiology and Immunology·D B RothM Gellert
Sep 1, 1991·Molecular and Cellular Biology·A L Kenter, J Tredup
Dec 1, 1990·Molecular and Cellular Biology·T CarterS DeLeon
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·F W Alt, D Baltimore
Aug 1, 1995·Current Opinion in Immunology·G E Taccioli, F W Alt
Jun 1, 1995·Immunology Today·W C Lin, S Desiderio
Apr 11, 1995·Proceedings of the National Academy of Sciences of the United States of America·S R PetersonD J Chen
Sep 25, 1994·Nucleic Acids Research·M OnoJ D Capra
Jun 1, 1994·Seminars in Immunology·S M Lewis
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·A SuwaJ A Hardin
Feb 11, 1993·Nucleic Acids Research·W DunnickC Gritzmacher
Jul 1, 1996·The Journal of Experimental Medicine·P D HodgkinA B Lyons
Aug 15, 1996·Genes & Development·M NachtT Jacks
Oct 1, 1996·Molecular and Cellular Biology·J S DanskaC J Guidos
Sep 17, 1996·Proceedings of the National Academy of Sciences of the United States of America·T BluntP A Jeggo
Mar 21, 1997·Journal of Molecular Biology·F Livák, D G Schatz
Mar 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·R ArakiM Abe
Jan 1, 1997·Annual Review of Immunology·A FischerF Le Deist
Jul 22, 1997·Proceedings of the National Academy of Sciences of the United States of America·Y GuF W Alt

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Citations

Sep 2, 2008·Molecular Biotechnology·Luciana R BertoliniJames D Murray
Dec 22, 2007·Nature Reviews. Immunology·Ulf Klein, Riccardo Dalla-Favera
Aug 6, 2009·Nature Structural & Molecular Biology·Shan ZhaFrederick W Alt
Oct 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Grace K MahowaldBarry P Sleckman
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cristian BoboilaFrederick W Alt
Dec 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Cosmas C GiallourakisFrederick W Alt
Feb 23, 2012·Proceedings of the National Academy of Sciences of the United States of America·Xiangyu LiuShan Zha
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Valentyn OksenychChunguang Guo
Mar 12, 2008·The Journal of Experimental Medicine·Christopher J JollyJohn P Manis
Feb 18, 2009·The Journal of Experimental Medicine·Beth A HelminkBarry P Sleckman
Feb 10, 2010·The Journal of Experimental Medicine·Cristian BoboilaFrederick W Alt
Jun 23, 2010·The Journal of Experimental Medicine·Shan ZhaFrederick W Alt
Dec 7, 2011·The Journal of Experimental Medicine·Duane R WesemannFrederick W Alt
Dec 28, 2011·The Journal of Experimental Medicine·Jeffrey J BednarskiBarry P Sleckman
Jan 22, 2008·Antioxidants & Redox Signaling·Fabio AltieriSilvia Chichiarelli
Sep 6, 2008·Nucleic Acids Research·Andrea KinnerGeorge Iliakis
Jan 8, 2013·Nucleic Acids Research·Mihai CiubotaruDavid G Schatz
Dec 24, 2008·Molecular and Cellular Biology·Beatriz Gozalbo-LópezMaría Luisa Gaspar
Feb 16, 2006·Molecular and Cellular Biology·Vyacheslav YurchenkoMoshe J Sadofsky
Mar 23, 2006·Annual Review of Immunology·David JungFrederick W Alt
Mar 29, 2008·Annual Review of Immunology·Janet StavnezerCarol E Schrader
Mar 16, 2007·PLoS Biology·Adam J L CookChristopher J Jolly
Sep 21, 2007·PLoS Biology·W Jason CummingsNancy Maizels
Jan 24, 2014·PLoS Genetics·Mireille BétermierBernard S Lopez
Jul 23, 2013·PloS One·Zheng LaiStephen Rea

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