The role of the nucleus accumbens shell in the mediation of the reinforcing properties of a safety signal in free-operant avoidance: dopamine-dependent inhibitory effects of d-amphetamine

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
A B P FernandoT W Robbins

Abstract

Safety signals (SSs) have been shown to reinforce instrumental avoidance behavior due to their ability to signal the absence of an aversive event; however, little is known of their neural mediation. This study investigated whether infusions of d-amphetamine in the nucleus accumbens (Nac), previously shown to potentiate responding for appetitive conditioned reinforcers (CRfs), also regulate avoidance responding for a SS. Rats were trained on a free-operant task in which lever-press responses avoided shock and were reinforced with an auditory SS. Rats were then cannulated in the Nac core (NacC) or shell (NacS) and infused with d-amphetamine and, in separate NacS groups, other drugs, before extinction sessions with the SS present or absent following responding. Selective effects of d-amphetamine were found in the NacS, but not in the NacC, when the SS was present in the session. A significant increase in response rate during the presentation of the SS reflected a disruption of its fear-inhibiting properties. In parallel, a decrease in avoidance response rate reflected the reduced influence of the SS as a CRf. Inactivation of the NacS reduced avoidance responding only when the SS was present in the session, whereas the D1-D2 DA rec...Continue Reading

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Citations

May 3, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Anushka FernandoTrevor Robbins
May 18, 2016·Brain : a Journal of Neurology·John D SalamoneMercè Correa
Sep 25, 2014·Annual Review of Psychology·Stan B Floresco
May 25, 2016·Behavioral and Brain Functions : BBF·Kevin Lloyd, Peter Dayan
Jan 7, 2015·PLoS Biology·Hiroaki Mano, Ben Seymour
May 28, 2019·Evolutionary Psychology : an International Journal of Evolutionary Approaches to Psychology and Behavior·Lesleigh E PullmanMichael C Seto
Jan 7, 2015·Current Protocols in Neuroscience·Anushka B P FernandoTrevor W Robbins
Jun 19, 2019·Proceedings of the National Academy of Sciences of the United States of America·Claire E StellyMatthew J Wanat
Nov 11, 2020·The American Journal of Psychiatry·Paola Odriozola, Dylan G Gee
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Jul 17, 2018·Neuropharmacology·Caitlin A OrsiniBarry Setlow
Jun 28, 2021·Behavioural Brain Research·Vincent D Campese

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