The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia.

Small GTPases
Fabian R VillagomezGenaro Patino-Lopez

Abstract

The study of cancer has allowed researchers to describe some biological characteristics that tumor cells acquire during their development, known as the "hallmarks of cancer" but more research is needed to expand our knowledge about cancer biology and to generate new strategies of treatment. The role that RabGTPases might play in some hallmarks of cancer represents interesting areas of study since these proteins are frequently altered in cancer. However, their participation is not well known. Recently, Rab35was recognized as an oncogenic RabGTPase and and because of its association with different cellular functions, distinctly important in immune cells, a possible role of Rab35 in leukemia can be suggested. Nevertheless, the involvement of Rab35 in cancer remains poorly understood and its possible specific role in leukemia remains unknown. In this review, we analyze general aspects of the participation of RabGTPases in cancer, and especially, the plausible role of Rab35 in leukemia.

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Citations

Apr 18, 2020·Technology in Cancer Research & Treatment·Yong ZhuJian Ding
Aug 28, 2020·International Journal of Molecular Sciences·Mary J O'Sullivan, Andrew J Lindsay
Jun 18, 2021·Small GTPases·Tushar Dubey, Subashchandrabose Chinnathambi
Aug 21, 2021·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Caitlin R Francis, Erich J Kushner
Nov 24, 2021·The Biochemical Journal·Sunayana DagarSivaram V S Mylavarapu

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Methods Mentioned

BETA
GTPase
GTPases

Software Mentioned

Cosmic

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