PMID: 8939405Dec 1, 1996Paper

The role of the oxidative state of glutathione and glutathione-related enzymes in anemia of hemodialysis patients

Clinical Biochemistry
H PaşaoğluC Utaş

Abstract

To investigate the oxidative state of glutathione and glutathione peroxidase (GSH-Px), glutathione reductase (GSSG-R), and glucose-6-phosphate dehydrogenase (G-6-PD) levels in patients with chronic renal failure (CRF) and controls. Erythrocyte GSH levels of patients were decreased, but GSSG was not significantly different from that of controls. Also, plasma GSH levels were not different, although GSSG was increased. GSSG/GSH ratios in erythrocyte and plasma were significantly higher in CRF patients. Erythrocyte GSSG-R activity was high, but G-6-PD and GPX were low. The findings suggest that: 1. Low GSH is related to decreased G-6-PD activities. 2. The reduction of peroxides with GPX are decreased by low GSH and low GPX activity. 3. GSSG may react with hemoglobin and causes protein aggregation in erythrocytes. These alterations cause hemolysis and could play a role in the pathogenesis of anemia in hemodialyzed patients.

Citations

Apr 11, 2020·Oxidative Medicine and Cellular Longevity·Maria Elena SotoIsrael Pérez-Torres
Jul 5, 2007·Bioscience Reports·Grazia De LucaLeonardo Romano
Dec 30, 2009·Biological Trace Element Research·Mohamed BushraIshag I Adam
Jan 6, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mohamed-Saiel S Alhamdani
May 12, 2009·Biological Trace Element Research·Ishraga I AbdelrahimI Adam
Feb 23, 2013·Obesity Facts·Lucie VávrováAleš Zák
Jun 24, 2005·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Alpay HaktanirCigdem Gokce
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