The role of the PGE2-aromatase pathway in obesity-associated breast inflammation

Cancer Discovery
Dingzhi Wang, Raymond N Dubois

Abstract

Subbaramaiah and colleagues present the first evidence indicating that a cyclooxygenase-2-prostaglandin E(2)-aromatase pathway promotes obesity-associated inflammation in women's breast tissues. Their findings shed new light on obesity-associated inflammation in general and provide a rationale for developing effective chemopreventive and therapeutic strategies targeting this pathway for obese women with breast inflammation and patients with hormone-dependent breast cancer.

References

Apr 20, 2006·Endocrine·Cristina M Rondinone
Oct 17, 2007·Breast Cancer Research and Treatment·Bilal MajedBernard Asselain
Jun 3, 2008·The Journal of Steroid Biochemistry and Molecular Biology·Louis Wing-Cheong ChowMasakazu Toi
Oct 9, 2008·Journal of the National Cancer Institute·Bahi TakkoucheMahyar Etminan
Feb 20, 2010·Nature Reviews. Cancer·Dingzhi Wang, Raymond N Dubois
Oct 22, 2010·The Journal of Biological Chemistry·Sarbani GhoshalCharles D Loftin
Nov 25, 2011·Nature Reviews. Cancer·Melin J KhandekarBruce M Spiegelman

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Citations

Jun 24, 2017·Breast Cancer Research and Treatment·Brandi L ClarkLandry K Kamdem
Sep 13, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yong CuiWei Zheng

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