The Role of the Placenta in Perinatal Stroke: A Systematic Review.

Journal of Child Neurology
Bithi RoyIona Novak

Abstract

Placental pathology may be an important missing link in the causal pathway of perinatal stroke. The study aim was to systematically review the literature regarding the role of the placenta in perinatal stroke. MEDLINE, Embase, Scopus, and Web of Science electronic databases were searched from 2000 to 2019. Studies were selected based on predefined criteria. To enable comparisons, placental abnormalities were coded using Redline's classification. Ten studies met the inclusion criteria. Less than a quarter of stroke cases had placental pathology reported. Placental abnormalities were more common among children with perinatal stroke than in the control group. The most frequent placental abnormality was Redline's category 2 (thrombo-inflammatory process). Placental abnormalities appear to be associated with perinatal stroke, supporting additional indirect evidence and biological plausibility of a causative role. However, the results should be interpreted cautiously considering the low frequency of placental examination and lack of uniformity in placental pathology reporting. PROSPERO Registration no: CRD42017081256.

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Citations

Jun 16, 2021·Nature Reviews. Neurology·Adam KirtonHelen L Carlson
Aug 11, 2021·Developmental Medicine and Child Neurology·Melissa VitaglianoAdam Kirton
Aug 20, 2021·Frontiers in Pediatrics·Mark S Scher

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