PMID: 4886043Mar 1, 1969Paper

The role of the platelet in the generalized Shwartzman reaction

The Journal of Experimental Medicine
W Margaretten, D G McKAY

Abstract

Rabbits were injected with an antiplatelet serum to produce selective thrombocytopenia without inducing a significant alteration of their leukocyte counts. Thrombocytopenic levels persisted for 8 hr after the injection of platelet antiserum. During this time, the generalized Shwartzman reaction could not be provoked with the second injection of endotoxin. Since platelet phospholipid is required for the formation of plasma thromboplastin, the results indicate that platelets are essential to the evolution of the generalized Shwartzman reaction and endotoxin triggers the intrinsic rather than the extrinsic clotting system to elicit the lesions.

References

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Citations

Apr 1, 1991·American Journal of Hematology·K OkajimaK Takatsuki
Feb 1, 1988·Immunology Today·A Billiau
Feb 1, 1987·Prostaglandins, Leukotrienes, and Medicine·H NagaiM Nakazawa
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Jun 1, 1976·Infection and Immunity·A H FromR A Good

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