The Role of the Polymeric Immunoglobulin Receptor and Secretory Immunoglobulins during Mucosal Infection and Immunity

Viruses
Holly Turula, Christiane E Wobus

Abstract

The gastrointestinal tract houses millions of microbes, and thus has evolved several host defense mechanisms to keep them at bay, and prevent their entry into the host. One such mucosal surface defense is the secretion of secretory immunoglobulins (SIg). Secretion of SIg depends on the polymeric immunoglobulin receptor (pIgR), which transports polymeric Ig (IgA or IgM) from the basolateral surface of the epithelium to the apical side. Upon reaching the luminal side, a portion of pIgR, called secretory component (SC) is cleaved off to release Ig, forming SIg. Through antigen-specific and non-specific binding, SIg can modulate microbial communities and pathogenic microbes via several mechanisms: agglutination and exclusion from the epithelial surface, neutralization, or via host immunity and complement activation. Given the crucial role of SIg as a microbial scavenger, some pathogens also evolved ways to modulate and utilize pIgR and SIg to facilitate infection. This review will cover the regulation of the pIgR/SIg cycle, mechanisms of SIg-mediated mucosal protection as well as pathogen utilization of SIg.

References

Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M B MazanecJ G Nedrud
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C S KaetzelM E Lamm
Jul 1, 1982·European Journal of Biochemistry·A Pierce-CretelJ F Vliegenthart
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·P FalkS Normark
Oct 27, 1998·Journal of Medical Microbiology·S D Dallas, R D Rolfe
Jan 9, 2001·Virchows Archiv : an International Journal of Pathology·T KanekoT Katsuyama
Mar 10, 2001·Acta Microbiologica Et Immunologica Hungarica·C RusznakS Lozewicz
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·L J MarshallJ K Shute
Sep 15, 2001·FEMS Microbiology Letters·I R de OliveiraL G Giugliano
Oct 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·F E JohansenP Brandtzaeg
Feb 5, 2002·Journal of Dental Research·A R HolmesR D Cannon
Aug 2, 2002·Immunity·Armelle PhaliponBlaise Corthésy
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nicholas J MantisMarian R Neutra
Jan 28, 2003·Trends in Immunology·Armelle Phalipon, Blaise Corthésy
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tania K UrenRichard A Strugnell
Jul 10, 2003·Vaccine·Philippe Van de Perre
Sep 26, 2003·Scandinavian Journal of Immunology·N MatsumotoI Moro
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacques ReyBlaise Corthésy
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keer SunDennis W Metzger
Nov 16, 2004·Expert Reviews in Molecular Medicine·Eleni-Kyriaki Vetsika, Margaret Callan
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tracey A SchneemanCharlotte S Kaetzel
Jul 22, 2005·The Journal of General Virology·Kasturi PalChristopher F Cuff
Jan 5, 2006·The Journal of Experimental Medicine·Odilia L C WijburgRichard A Strugnell
Mar 18, 2006·The Journal of Biological Chemistry·Clémentine PerrierBlaise Corthésy
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Barbara J DavidsLars Eckmann

❮ Previous
Next ❯

Citations

Jul 16, 2019·Journal of Leukocyte Biology·Rebecca Blandino, Nicole Baumgarth
Dec 29, 2019·The Journal of Nutrition·Robert L BeverlyDavid C Dallas
Mar 26, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Giuliana MedranoAnkush Gosain
Apr 17, 2020·JCI Insight·Juan HuangLi Wen
Dec 26, 2018·Clinical Kidney Journal·Thomas WeimbsBryan C Bourgeois
May 16, 2020·Frontiers in Immunology·Andreas FreyMichael Wegmann
Feb 8, 2020·Science·Yaxin LiJunyu Xiao
Aug 25, 2020·SN Comprehensive Clinical Medicine·T K Sivabakya, G Srinivas
Apr 11, 2019·Frontiers in Immunology·Jun LiuJi-Yang Wang
Aug 28, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ariane LechasseurMathieu C Morissette
Nov 13, 2020·Frontiers in Veterinary Science·Johanna AnturaniemiAnna Hielm-Björkman
Aug 5, 2020·The Journal of Allergy and Clinical Immunology·Stephen Shih-Teng KaoAlkis James Psaltis
Nov 13, 2020·The Journal of Biological Chemistry·Weikang SunWeiwei Li
Oct 28, 2020·Mucosal Immunology·Evelyn CampbellCathryn R Nagler
Dec 10, 2020·International Journal of Molecular Sciences·Bernadeta PietrzakMarcin Schmidt
Feb 14, 2021·Biology·Umberto OresteMaria Rosaria Coscia
Jan 19, 2021·The Journal of Biological Chemistry·Weikang SunWeiwei Li
Mar 7, 2021·International Journal of Molecular Sciences·Hao Wei, Ji-Yang Wang
Mar 4, 2021·Nature Medicine·Christoph MuusUNKNOWN Human Cell Atlas Lung Biological Network
Mar 11, 2021·Journal of Biotechnology·Venugopal BhaskaraEmilio Casanova
Mar 18, 2021·Expert Review of Clinical Immunology·Harsha H Kariyawasam, Louisa K James
Mar 20, 2021·Cell·Caroline Atyeo, Galit Alter
Apr 20, 2021·Plant Molecular Biology·Katsuhiro NakanishiYasuyuki Imai
Jun 16, 2021·The Journal of Surgical Research·Özgür İkizTülin Fırat
Jun 18, 2021·Cell Systems·Vadim DemichevFlorian Kurth
Jul 28, 2021·Human Vaccines & Immunotherapeutics·Alison Schaefer, Samuel K Lai
Aug 7, 2021·Journal of the Science of Food and Agriculture·Su Jung HwangHyo-Jong Lee

❮ Previous
Next ❯

Methods Mentioned

BETA
glycosylations
glycosylation

Related Concepts

Related Feeds

Antibodies: Agglutination

Antibody-mediated agglutination is the clumping of cells in the presence of antibody, which binds multiple cells together. This enhances the clearance of pathogens. Find the latest research on antibody-mediated agglutination here.

Antibodies: Complement Activation

The complement system can be activated by antigen-associated antibody. In the classical pathway of complement activation, C1q, C4b, and C3b are all able to bind to the Fc portion of IgG or IgM. Find the latest research on antibodies and complement activation here.