The role of the polyol pathway in acute kidney injury caused by hindlimb ischaemia in mice

The Journal of Pathology
Soroku YagihashiStephen S M Chung

Abstract

The polyol pathway, a collateral glycolytic process, previously considered to be active in high glucose milieu, has recently been proposed to play a crucial role in ischaemia/reperfusion tissue injury. In this study, we explored the role of the polyol pathway in acute kidney injury (AKI), a life-threatening condition, caused by hindlimb ischaemia, and determined if inhibition of the polyol pathway by aldose reductase (AR) inhibitor is beneficial for this serious disorder. Mice 8 weeks of age rendered hindlimb ischaemic for 3 h by the clipping of major supporting arteries revealed marked muscle necrosis with accumulation of sorbitol and fructose in ischaemic muscles. Serum concentrations of blood urea nitrogen (BUN), creatinine phosphokinase (CPK), creatinine, tumour necrosis factor (TNF)-alpha as well as interleukin (IL)-6 were all elevated in these mice. Treatment with AR inhibitor (ARI) effectively suppressed muscle necrosis and accompanying inflammatory reactions and prevented renal failure. Similar to ARI-treated mice, AR-deficient mice were protected from severe ischaemic limb injury and renal failure, showing only modest muscle necrosis and significant suppression of serum markers of renal failure and inflammation. Thus, ...Continue Reading

References

Sep 1, 1993·Journal of Neuropathology and Experimental Neurology·H NukadaR R Myers
May 16, 1998·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·C Nishimura-Yabe
Aug 5, 1998·The American Journal of Physiology·R RamasamyS Schaefer
Jul 27, 2000·Molecular and Cellular Biology·H T HoS S Chung
Sep 27, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gülçin KantarciEmel Akoglu
Jul 31, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuying C HwangRavichandran Ramasamy
Mar 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuying C HwangRavichandran Ramasamy
Jul 20, 2005·Current Drug Targets·S S M Chung, S K Chung
Nov 23, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Kazuhiro KanekoKatsuo Sueishi
Dec 2, 2005·Muscle & Nerve·Masayuki BabaSoroku Yagihashi
Mar 29, 2006·The Journal of Biological Chemistry·Karin KaiserovaAruni Bhatnagar
Aug 29, 2006·Journal of Pharmacological Sciences·Kazumi IwataChihiro Yabe-Nishimura
Feb 13, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Amy C Y LoSookja K Chung
Jul 27, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ryan M LevyTimothy R Billiar
Aug 19, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Matthias BehrendsClaus U Niemann
Aug 31, 2007·Experimental Eye Research·Alvin K H CheungSookja K Chung
Jan 29, 2008·Current Drug Targets·Peter J Oates
Feb 23, 2008·Seminars in Liver Disease·Vicente ArroyoPere Ginès
Jul 18, 2008·Critical Care Medicine·Kevin K ChungJames D Oliver
Dec 17, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·H Thomas LeeVivette D D'Agati

❮ Previous
Next ❯

Citations

Dec 27, 2011·International Journal of Clinical Oncology·Yasuhiro HashimotoChikara Ohyama
Jan 24, 2011·Journal of Diabetes Investigation·Soroku YagihashiKazuhiro Sugimoto
Jun 2, 2010·International Journal of Molecular Medicine·Irina G ObrosovaCarl-David Agardh
Dec 7, 2010·European Journal of Clinical Investigation·Hiroki MizukamiSoroku Yagihashi
Dec 17, 2010·European Journal of Clinical Investigation·Kak K YeungGeert-Jan Tangelder
Jun 27, 2014·Oxidative Medicine and Cellular Longevity·Changhe ZhangXiangcheng Li
Jan 24, 2017·Chemico-biological Interactions·Mahavir SinghAruni Bhatnagar
Apr 15, 2016·American Journal of Physiology. Cell Physiology·Stéphanie ParadisBernard Geny
Feb 15, 2017·Nature Communications·Ana Andres-HernandoMiguel A Lanaspa
Aug 18, 2021·Metabolism: Clinical and Experimental·Spencer G MillerJeffrey J Brault

❮ Previous
Next ❯

Related Concepts

Related Feeds