PMID: 16637300Apr 28, 2006Paper

The role of the preoperative radiochemotherapy and the role of neoadjuvant chemotherapy before radical Wertheim-Meigs hysterectomy for cervical cancer stage I B - II B

Akusherstvo i ginekologii︠a︡
S Ivanov, Angel Kŭrlov

Abstract

One of the most important prognostic factors for early stages cervical cancers is the tumour size. The patients with size of the tumour bigger than 4 sm in diameter have worse prognosis. The aim of our research work was to compare the efficacy of preoperative radiochemotherapy and neoadjuvant intravenous chemotherapy, followed by radical hysterectomy a modo Wertheim-Meigs for stage I B - II B cervical cancer. We summerized our and foreign experience in this field. From 1998 till 2005 we examined 123 patients in stage I B - II B cervical cancer treated by preoperative percutaneous radiotherapy (dosis 45 Gy) plus cisplatin (50 mg/m2) compared with preoperative chemotherapy cisplatin (50 mg/m2), vincristin 1 mg/m2 every 7-10 days for 3 courses. Radical hysterectomy a modo Wertheim-Meigs was performed 4-5 weeks after the preoperative treatment. There is no significant difference in the age groups, stages of the tumour, the tumour size end the histopathological kind of the tumour between the 2 groups of examined patients. The toxicity in the two groups was mild. In the group with preoperative radiochemotherapy 4 patients developed vesicovaginal fistulas, 3 patients hydronephrosis. After the surgical treatment the invasion of the tum...Continue Reading

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