The Role of the Programmed Death Receptor-1/Programmed Death Ligand-1: Immunologic Checkpoint in Human Papillomavirus-Associated Head and Neck Squamous Cell Carcinoma

Archives of Pathology & Laboratory Medicine
Christine Kunkle, Flavia G Rosado

Abstract

- There has been increasing interest in understanding the role of programmed death receptor-1 (PD-1)/programmed death ligand-1 (PD-L1) pathway in cancer biology and its clinical significance in cancer therapy. - To discuss the studies of the PD-1/PD-L1 pathway in human papillomavirus-positive head and neck squamous cell carcinoma, focusing on the pathogenesis of cancer, characterization of the tumor microenvironment, and the effect of such studies in laboratory medicine. - Data sources included peer-reviewed literature and reputable online sources. - To date, there are few studies of PD-1 and PD-L1 in human papillomavirus-positive head and neck squamous cell carcinoma. There is evidence that the PD-1/PD-L1 pathway has a role in this type of cancer; however, further studies are needed to better characterize the effect of the human papillomavirus and its use as a marker of therapy response.

References

Sep 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Yoshiko IwaiNagahiro Minato
Apr 22, 2003·Nature Medicine·Tyler J CurielWeiping Zou
Aug 24, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shahnaz BegumWilliam H Westra
Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
Mar 31, 2011·Infectious Agents and Cancer·Giuseppe PannonePantaleo Bufo
Jan 25, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael R GreenMargaret A Shipp
Mar 23, 2012·Nature Reviews. Cancer·Drew M Pardoll
Oct 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Patrick A OttCaroline Robert
Apr 10, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Janis M TaubeRobert A Anders
Oct 30, 2015·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Hae Su KimMyung-Ju Ahn
Jan 19, 2016·Archives of Pathology & Laboratory Medicine·Lynette M ShollUNKNOWN Members of Pulmonary Pathology Society

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