The role of the reactions of .NO with superoxide and oxygen in biological systems: a kinetic approach

Free Radical Biology & Medicine
G Czapski, S Goldstein

Abstract

In this study we calculate the half-life of .NO in its reactions with superoxide and with oxygen under various conditions using the known rate constants for these reactions. The measured half-life of .NO in biological systems is 3-5 s, which agrees well with the calculated value for intracellular .NO, but not for extracellular .NO under normal physiological conditions. The autoxidation of .NO to yield NO2- as a final product cannot be responsible for such a short measured half-life under normal as well as pathologic conditions. Therefore, if there is direct evidence for the occurrence of the reaction of .NO with O2.- in the medium, one has to assume that the steady state concentrations of free .NO are much lower than those measured. The very low concentrations of free .NO in biological systems may result from its reversible strong binding to biological molecules. Simulation of the mechanism of the autoxidation of .NO indicates that the binding constants of .NO to O2 or to another .NO are too small to account for the very low concentration of free .NO in biological systems. Nevertheless, the reaction of .NO with oxygen cannot be neglected in biological systems if the intermediate ONOO. reacts rapidly with a biological target. Th...Continue Reading

References

Nov 1, 1992·Chemical Research in Toxicology·W H KoppenolJ S Beckman
Nov 1, 1992·Archives of Biochemistry and Biophysics·J S BeckmanM Tsai
Jan 1, 1991·Free Radical Research Communications·J A Imlay, I Fridovich
Aug 1, 1991·Archives of Biochemistry and Biophysics·R RadiB A Freeman
Nov 12, 1991·European Journal of Pharmacology·J P NowickiB Scatton
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·L J Ignarro
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J A GallyG M Edelman
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Dec 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S MoncadaR J Gryglewski
Nov 30, 1988·Biochemical and Biophysical Research Communications·J B HibbsE M Rachlin
Oct 18, 1988·European Journal of Pharmacology·M Kelm, J Schrader
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·I Fridovich
Oct 1, 1995·Free Radical Biology & Medicine·S Goldstein, G Czapski
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroR E Byrns
May 1, 1995·The American Journal of Physiology·W A Pryor, G L Squadrito
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·W A PryorG L Squadrito
Jul 1, 1994·Chemical Research in Toxicology·R S Lewis, W M Deen
Jul 12, 1993·FEBS Letters·P C FordD M Stanbury
May 1, 1993·Biochemical Society Transactions·J S Beckman, J P Crow
Jan 1, 1993·Free Radical Research Communications·R E Huie, S Padmaja

❮ Previous
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Citations

Jul 26, 2012·Theory in Biosciences = Theorie in Den Biowissenschaften·Paula Mariela GonzálezSusana Puntarulo
Dec 19, 2003·Free Radical Biology & Medicine·Dirk TaubertRenate Roesen
Jun 17, 1998·Free Radical Biology & Medicine·P ManningE W Hillhouse
May 29, 2000·Pathophysiology : the Official Journal of the International Society for Pathophysiology·J Ahlqvist
Jun 25, 2008·The British Journal of Nutrition·Siegfried KnasmüllerKarl-Heinz Wagner
Jul 11, 2012·Chemical Research in Toxicology·Kevin M NashFrederick A Villamena
Jul 26, 2003·Antioxidants & Redox Signaling·Douglas D ThomasDavid A Wink
Apr 4, 2012·Antioxidants & Redox Signaling·Katarzyna A Broniowska, Neil Hogg
Feb 19, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ok-Nam BaeJin-Ho Chung
Sep 28, 2006·Annual Review of Pharmacology and Toxicology·Yoshito Kumagai, Daigo Sumi
May 9, 2009·Journal of Inflammation·Catherine A ShawIan L Megson
Mar 23, 2010·Biological Chemistry·Utta Berchner-PfannschmidtMichael Kirsch
Jul 11, 2000·Clinical and Experimental Immunology·B ChandrasekarG L Freeman
Sep 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·Douglas D ThomasDavid A Wink
Mar 18, 1996·FEBS Letters·N HoggB Kalyanaraman
Jan 23, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Elizabeth R AxtonJan F Stevens
Sep 6, 2011·Journal of Pharmaceutical and Biomedical Analysis·Soyoung Shin, Ho-Leung Fung
Mar 22, 2013·Chemical Reviews·Candice E Paulsen, Kate S Carroll
Jul 29, 2008·Biomaterials·Gregory W CharvilleMark H Schoenfisch
Jan 16, 2007·Nitric Oxide : Biology and Chemistry·Kris T HuangDaniel B Kim-Shapiro
Oct 20, 2006·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·H M H van EijkN E P Deutz
Aug 5, 2008·Journal of Pineal Research·Utta Berchner-PfannschmidtMichael Kirsch
Oct 4, 2007·Journal of Pineal Research·Anna KopczakMichael Kirsch
Jul 19, 2012·Transfusion·Robert M Winslow
Mar 30, 2016·Nitric Oxide : Biology and Chemistry·Kurt VranckenArlin B Blood
Apr 25, 2006·Free Radical Biology & Medicine·Roman KöhlBernhard Brüne
Sep 7, 2012·Free Radical Biology & Medicine·Kumpal MadrasiNikolaos M Tsoukias
Dec 16, 1998·Nitric Oxide : Biology and Chemistry·A DaiberV Ullrich
Sep 23, 2014·Free Radical Biology & Medicine·Bernd KolesnikAntonius C F Gorren
May 11, 2013·Free Radical Biology & Medicine·Bernd KolesnikAntonius C F Gorren
Mar 14, 2002·Nitric Oxide : Biology and Chemistry·Adrian P L SmithTim W Higenbottam
Dec 19, 2014·Molecular BioSystems·D W Bak, E Weerapana

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