The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults

Oxidative Medicine and Cellular Longevity
Małgorzata Nita, Andrzej Grzybowski

Abstract

The reactive oxygen species (ROS) form under normal physiological conditions and may have both beneficial and harmful role. We search the literature and current knowledge in the aspect of ROS participation in the pathogenesis of anterior and posterior eye segment diseases in adults. ROS take part in the pathogenesis of keratoconus, Fuchs endothelial corneal dystrophy, and granular corneal dystrophy type 2, stimulating apoptosis of corneal cells. ROS play a role in the pathogenesis of glaucoma stimulating apoptotic and inflammatory pathways on the level of the trabecular meshwork and promoting retinal ganglion cells apoptosis and glial dysfunction in the posterior eye segment. ROS play a role in the pathogenesis of Leber's hereditary optic neuropathy and traumatic optic neuropathy. ROS induce apoptosis of human lens epithelial cells. ROS promote apoptosis of vascular and neuronal cells and stimulate inflammation and pathological angiogenesis in the course of diabetic retinopathy. ROS are associated with the pathophysiological parainflammation and autophagy process in the course of the age-related macular degeneration.

References

Feb 1, 1977·Experimental Eye Research·J G Jose, K L Yielding
Jan 1, 1992·Free Radical Biology & Medicine·J W Park, R A Floyd
Feb 4, 1972·Science·A U ArstilaB F Trump
Dec 1, 1995·The American Journal of Clinical Nutrition·H Sies, W Stahl
Jan 1, 1994·Annual Review of Biochemistry·D S Bredt, S H Snyder
Dec 8, 2000·Biochimica Et Biophysica Acta·A M SchmidtD M Stern
Apr 5, 2001·Progress in Retinal and Eye Research·J FlammerT Resink
Oct 31, 2001·Journal of Photochemistry and Photobiology. B, Biology·M J Davies, R J Truscott
Dec 6, 2001·Trends in Molecular Medicine·D A ButterfieldA Castegna
Jan 5, 2002·Physiological Reviews·Wulf Dröge
Feb 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rajeev BuddiDonald J Brown
Nov 13, 2002·Mutation Research·Bhaskar S MandavilliBennett Van Houten
Feb 26, 2003·Investigative Ophthalmology & Visual Science·Xiaoping QiJohn Guy
Mar 22, 2003·Journal of Cataract and Refractive Surgery·Joseph Colin, Sylvie Velou
Apr 18, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Vladimir BantseevJacob G Sivak
Apr 26, 2003·Investigative Ophthalmology & Visual Science·Janet R SparrowBolin Cai
Sep 18, 2003·Ophthalmology·C P WilkinsonUNKNOWN Global Diabetic Retinopathy Project Group
Jan 1, 2004·American Journal of Ophthalmology·Sandra M FerreiraSusana F Llesuy
Jan 2, 2004·The New England Journal of Medicine·Robert N Frank
Apr 8, 2004·Clinical & Experimental Ophthalmology·Trevor Sherwin, Nigel H Brookes
Apr 14, 2004·Archives of Ophthalmology·Marco A Zarbin
May 26, 2004·Lancet·Robert N Weinreb, Peng Tee Khaw
Sep 3, 2004·Mutation Research·Mark D EvansMarcus S Cooke
Sep 24, 2004·Free Radical Biology & Medicine·María Cecilia MorenoRuth E Rosenstein
Oct 27, 2004·Investigative Ophthalmology & Visual Science·Gülgün Tezel, Xiangjun Yang
Dec 22, 2004·Progress in Retinal and Eye Research·Thomas F LinsenmayerJohn M Fitch
Feb 25, 2005·Investigative Ophthalmology & Visual Science·Doina GherghelSarah Louise Hosking
Feb 25, 2005·Investigative Ophthalmology & Visual Science·Juan E GrunwaldMaureen G Maguire
Mar 26, 2005·Investigative Ophthalmology & Visual Science·Shari R AtilanoM Cristina Kenney
May 3, 2005·Experimental Eye Research·Janet R Sparrow, Mike Boulton
May 3, 2005·Experimental Eye Research·Roger J W Truscott
May 21, 2005·Seminars in Cell & Developmental Biology·Thomas Kietzmann, Agnes Görlach
Jun 21, 2005·Journal of Cellular Physiology·Lili LuPeter A Campochiaro
Sep 28, 2005·Investigative Ophthalmology & Visual Science·Kyle I SwansonLeonard A Levin
Sep 28, 2005·Investigative Ophthalmology & Visual Science·Nina C B B TaarnhøjMichael Larsen

❮ Previous
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Citations

Sep 12, 2013·Acta Biomaterialia·Ivonne BartschFrank Witte
Jul 29, 2016·Experimental and Molecular Pathology·M L PerepechaevaA Y Grishanova
Jul 20, 2016·Ophthalmology·Seong Hee ShimUNKNOWN Epidemiologic Survey Committee of the Korean Ophthalmological Society
Aug 2, 2016·Mitochondrion·Nuri GuevenJamuna Chhetri
Sep 7, 2016·Oxidative Medicine and Cellular Longevity·Cheng WanChun Zhang
Sep 17, 2016·Oxidative Medicine and Cellular Longevity·Patrícia Ioschpe GusLuciene Barbosa
Oct 1, 2016·Oxidative Medicine and Cellular Longevity·Janusz BlasiakKai Kaarniranta
Jan 8, 2015·Indian Journal of Dentistry·Abhishek Mehta, Gurkiran Kaur
Nov 2, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annia GalanoRussel J Reiter
May 6, 2017·Oxidative Medicine and Cellular Longevity·Shehzad BatliwalaIok-Hou Pang
Jan 4, 2018·Pharmaceuticals·Paul Chukwudi IkwegbueAbidemi Paul Kappo
Mar 31, 2018·Journal of Cellular Physiology·Jacopo PizzicannellaOriana Trubiani
Feb 2, 2018·Environmental Science and Pollution Research International·Yoon-Hyeong ChoiDong Hyun Kim
Jan 6, 2018·Cornea·Necip KaraKıvanc Gungor
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Cody R Fisher, Deborah A Ferrington
Sep 11, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Seung-Jun SeoJong-Ki Kim
Oct 3, 2018·Cutaneous and Ocular Toxicology·Erel IcelHalis Süleyman
Nov 28, 2018·Journal of Cellular Physiology·Mahbobeh SatariZatollah Asemi
Jul 14, 2018·Eye & Contact Lens·Caterina SarnicolaKathryn Colby
Nov 27, 2018·Translational Neuroscience·Qing YangLin Luo
Jan 23, 2019·Environmental Science and Pollution Research International·Maryam ShiraniMohammad Amin Dehghani
Jan 27, 2019·Cutaneous and Ocular Toxicology·Ayhan VurmazAbdülkadir Bilir
May 20, 2019·Environmental Science and Pollution Research International·Sahar M MahmoudNabil A El-Yamany
Sep 8, 2019·Environmental Science and Pollution Research International·Archanaa SundararaghavanGadi K Suraishkumar
Jul 26, 2019·Journal of Ophthalmology·Altaf A KondkarSaleh A Al-Obeidan

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Methods Mentioned

BETA
protein folding
MDA

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