The role of the renin angiotensin hormonal system in the metabolic syndrome and type 2 diabetes

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
R Nosadini, G Tonolo

Abstract

Potentially important new findings have recently been reported concerning the so-called metabolic syndrome in relation to the renin-angiotensin system, ie, that treatment with inhibitors of the angiotensin-converting enzyme (ACE) not only decreases blood pressure levels but prevents the development of diabetes mellitus. The new findings described in this article highlight the potential role of the ACE system in the regulation of insulin sensitivity, thus contributing to the development of type 2 diabetes and metabolic syndrome. In addition to the well known selective effects of ACE inhibitors and angiotensin II receptor blockers in reducing microalbuminuria in diabetic patients, the potential ability of these drugs to reduce the risk of diabetes and the metabolic syndrome would support their use as first line agents not only in diabetic patients but also in selected groups of hypertensive patients, who are particularly at risk of developing metabolic complications. This information supports the Joint Guidelines for the Management of Arterial Hypertension by the European Society of Hypertension and the European Society of Cardiology, which highlight the crucial role of ACE inhibitors and the angiotensin II receptor blockers in p...Continue Reading

References

Jul 18, 2001·Current Opinion in Nephrology and Hypertension·K Tryggvason, J Wartiovaara
Nov 29, 2002·The New England Journal of Medicine·Manfred Boehm, Elizabeth G Nabel
Dec 20, 2002·JAMA : the Journal of the American Medical Association·UNKNOWN ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatm
Dec 17, 2002·JAMA : the Journal of the American Medical Association·Lawrence J Appel
Jan 10, 2003·The New England Journal of Medicine·Gunhild KellerKerstin Amann
May 16, 2003·JAMA : the Journal of the American Medical Association·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee

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Citations

Sep 8, 2010·European Journal of Internal Medicine·Lucia Maria ProcopciucDumitru Zdrenghea
Aug 19, 2007·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Ferruccio Galletti, Pasquale Strazzullo
May 14, 2005·Circulation Research·Anders H Berg, Philipp E Scherer
Jul 28, 2006·American Journal of Physiology. Cell Physiology·Puja K Mehta, Kathy K Griendling
Jul 26, 2019·Oxidative Medicine and Cellular Longevity·Sebastian StevenAndreas Daiber

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