The role of the renin-angiotensin system in skin physiology and pathophysiology.

Experimental Dermatology
Igor Maciel Souza SilvaUlrike Muscha Steckelings

Abstract

Since its first description around the year 2000, the local renin-angiotensin system (RAS) in skin has been subject of an increasing number of studies with many additions over the last two to three years. A focus of research has been investigations on the role of cutaneous angiotensin receptors and locally synthesised angiotensin II in wound healing, in dermatoses associated with skin fibrosis and in melanoma. This review will provide an introduction into the RAS with emphasis on information relevant for the cutaneous RAS. It will discuss the role of the RAS in skin physiology, followed by a detailed review of the existing literature addressing the role of local angiotensin II and angiotensin AT1 and AT2 receptors in wound healing and in various skin diseases such as hypertrophic scars/keloids, scleroderma, dystrophic epidermolysis bullosa, Dupuytren's disease, squamous cell carcinoma, melanoma and psoriasis. In a final section, the potential relevance of drugs, which interfere with the RAS, for future therapy of dermatological disorders is discussed. Collectively, research about the RAS in skin can currently be described as an area, which has gained increasing attention by basic researchers, thus resulting in a multitude of pr...Continue Reading

References

Sep 16, 1992·Biochemical and Biophysical Research Communications·B KimuraM I Phillips
Dec 13, 1985·Clinica Chimica Acta; International Journal of Clinical Chemistry·K W RyderM R Glick
Apr 1, 1982·The British Journal of Dermatology·P C van de Kerkhof
Dec 4, 1996·Biochemical and Biophysical Research Communications·U M SteckelingsB M Henz
Apr 20, 1999·Biochemical and Biophysical Research Communications·R KranzhöferW Kübler
Jan 5, 2000·The Journal of Investigative Dermatology·B HermesB M Henz
Jun 26, 2001·The British Journal of Dermatology·H Takeda, S Kondo
Sep 5, 2002·The British Journal of Dermatology·C Marquart-ElbazD Lipsker
Mar 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thomas E ScholzenThomas A Luger
Jul 4, 2003·The Journal of Clinical Investigation·Kimiyasu EgamiTsutomu Imaizumi
Feb 28, 2004·Experimental Dermatology·U Muscha SteckelingsMetin Artuc
May 5, 2004·The Journal of Biological Chemistry·Sandrine NouetClara Nahmias
Oct 29, 2004·The American Journal of Pathology·Hikaru TakedaShigeo Kondo
Oct 18, 2005·The British Journal of Dermatology·U M SteckelingsM Artuc
Jan 31, 2006·Journal of the American Academy of Dermatology·Kiyoshi MoriharaSaburo Kishimoto
Apr 22, 2008·Journal of Dermatological Science·Kozo NakaiYasuo Kubota
Apr 7, 2010·Drug News & Perspectives·Franziska RompeUlrike Muscha Steckelings
Oct 23, 2010·Nature Reviews. Cancer·Amee J GeorgeRoss D Hannan
Nov 18, 2010·Annals of the Rheumatic Diseases·Gabriela RiemekastenDuska Dragun
Dec 13, 2012·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Sachin S JadhavKathleen E Rodgers
Jan 22, 2013·Arthritis and Rheumatism·Wioleta MarutFrédéric Batteux
Feb 1, 2013·Nature·Sébastien FoulquierThomas Unger
Feb 15, 2013·Experimental and Therapeutic Medicine·Xianglin DongYing Cen
Feb 16, 2013·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Gwan Gyu SongYoung Ho Lee
Oct 9, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andrew S CowburnRandall S Johnson
Sep 3, 2014·American Journal of Respiratory and Critical Care Medicine·Mike O BeckerGabriela Riemekasten
Oct 28, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Tosan EhanireHoward Levinson
Apr 8, 2015·Trends in Pharmacological Sciences·Danielle Gomes Passos-SilvaRobson Augusto Souza Santos
May 8, 2015·Fibrogenesis & Tissue Repair·Amanda M MurphyMichael Bezuhly
Jun 13, 2015·Clinical, Cosmetic and Investigational Dermatology·Satoru Shinkuma
Jul 22, 2015·EMBO Molecular Medicine·Alexander NyströmLeena Bruckner-Tuderman
Dec 3, 2015·Current Opinion in Nephrology and Hypertension·Randall S JohnsonRichard Weller
Dec 13, 2016·Annals of the Rheumatic Diseases·Otylia Kowal-BieleckaUNKNOWN EUSTAR Coauthors
Dec 16, 2016·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Heiko SorgUrsula Mirastschijski
May 10, 2017·Journal of Plastic Surgery and Hand Surgery·Christopher StephenStuart McKirdy
Aug 6, 2017·Autoimmunity Reviews·Melvin Berger, Virginia D Steen
Nov 15, 2017·Mechanisms of Ageing and Development·Dimitra Kiritsi, Alexander Nyström

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