PMID: 9538687Apr 16, 1998Paper

The role of the ribosome-translocon complex in translation and assembly of polytopic membrane proteins

Trends in Biochemical Sciences
E Bibi

Abstract

Newly synthesized polytopic membrane proteins and secretory proteins often share the same target membrane as their primary destination, and in some cases, the cellular machinery that targets and transfers them into or across the membrane. Unlike secretory proteins, which are localized to the external compartment, each polytopic membrane protein molecule must be partitioned among the cytoplasm, the membrane and the external milieu. How does the ribosome-translocon complex cope with the different domains of polytopic membrane proteins?

References

Apr 5, 1992·Journal of Molecular Biology·J Calamia, C Manoil
Nov 4, 1985·Nature·M Friedlander, G Blobel
Oct 25, 1985·Science·W T Wickner, H F Lodish
Jan 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G von Heijne
Jan 1, 1994·Annual Review of Cell Biology·P Walter, A E Johnson
Jul 1, 1996·The Journal of Cell Biology·D T NgP Walter
Jan 1, 1996·Annual Review of Biochemistry·T A RapoportU Kutay
Jan 17, 1997·The Journal of Biological Chemistry·V Laird, S High
Jul 16, 1997·The EMBO Journal·W van KlompenburgB de Kruijff
Apr 1, 1996·Trends in Cell Biology·B Martoglio, B Dobberstein
May 1, 1997·Trends in Cell Biology

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Citations

Sep 28, 2005·Nature Structural & Molecular Biology·Heather SadlishWilliam R Skach
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·R BeutlerB Erni
Jun 28, 2000·Proceedings of the National Academy of Sciences of the United States of America·H DaleM P Krebs
Jul 6, 2000·Proceedings of the National Academy of Sciences of the United States of America·A B Weinglass, H R Kaback
Sep 12, 2000·Molecular Biology of the Cell·Y LuW R Skach
Sep 9, 2006·Microbiology and Molecular Biology Reviews : MMBR·M J J B SibbaldJ M van Dijl
Mar 8, 2000·Microbiology and Molecular Biology Reviews : MMBR·M van Geest, J S Lolkema
Jul 20, 1999·Annual Review of Biophysics and Biomolecular Structure·S H White, W C Wimley
Jun 25, 2008·Annual Review of Biophysics·Stephen H White, Gunnar von Heijne
Jun 5, 2014·Annual Review of Biophysics·Karen G Fleming
Jun 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Matthias Quick, Ernest M Wright
Jan 30, 2008·Molecular and Cellular Endocrinology·Yael Gur, Haim Breitbart
Sep 4, 2007·Biochemical and Biophysical Research Communications·Andrea MaggioniJoe Tiralongo
Feb 27, 1999·Current Opinion in Structural Biology·P J Booth, A R Curran
Aug 31, 2000·Annual Review of Biochemistry·J L Popot, D M Engelman
Nov 19, 2015·Frontiers in Microbiology·Shivani GoolabMichael C Crampton
Apr 17, 1999·The Journal of Biological Chemistry·R MathurG Koren
Oct 17, 1998·The Journal of Biological Chemistry·K OtaK Mihara

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