The role of the sarcolemma action potential in fatigue

Advances in Experimental Medicine and Biology
A J Fuglevand

Abstract

A prevalent feature of neuromuscular fatigue is a decline in the extracellularly recorded myoelectric signal. One factor that could underlie this change is a decrease in the amplitude of the sarcolemmal action potential. Based on observed reductions in action potential amplitude without effect on force, it has been argued that changes in the action potential during sustained activity would be unlikely to contribute to fatigue. However, those observations were primarily from experiments in which 1) high frequency stimulation may have caused signal cancellation due to action potential overlap; or 2) sustained membrane depolarization may have directly activated excitation-contraction coupling. The relatively low and narrow range of membrane depolarization required for full activation of amphibian and slow-twitch mammalian fibers makes them resistant to incomplete activation if action potentials are depressed during fatigue. Mammalian fast-twitch fibers, on the other hand, require greater depolarization for full activation and also exhibit a greater decrease in action potential amplitude with fatigue. Therefore, it seems probable that fatigue-related decline in action potential amplitude in these fibers leads to incomplete activati...Continue Reading

Citations

Jul 13, 2002·Muscle & Nerve·Christiana DelloRussoRalph F Fregosi
Apr 30, 2003·The Journal of Physiology·Andrew J Fuglevand, Douglas A Keen
Nov 4, 2005·Journal of Neurophysiology·C K ThomasB Bigland-Ritchie
Jul 28, 2012·Journal of Applied Physiology·Bradley M Pitman, John G Semmler
Oct 29, 2002·Muscle & Nerve·Ya-Ju Chang, Richard K Shields
Mar 4, 2006·The Journal of Physiology·C S KleinC K Thomas
Apr 23, 2005·Journal of Applied Physiology·Morgan LévénezJacques Duchateau
Jul 28, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Arthur LoTimothy W Secomb
Dec 19, 2008·Journal of Neurophysiology·Kori SchmittRalph F Fregosi
Oct 12, 2011·Journal of Strength and Conditioning Research·Emil SundstrupLars L Andersen
Nov 8, 2005·Experimental Brain Research·Kevin G KeenanRoger M Enoka
May 13, 1998·Acta Physiologica Scandinavica·P K LundeO M Sejersted

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