PMID: 2499134Mar 1, 1989Paper

The role of the spleen in the neuroinvasion of scrapie in mice

Virus Research
R H Kimberlin, C A Walker

Abstract

The pathogenesis of 139A scrapie has been studied in CW mice infected intraperitoneally (i.p.), intravenously (i.v.) or subcutaneously (s.c.). In mice splenectomised before i.p. infection, the evidence points to a neuroinvasive pathway from visceral lymph nodes (and other sites of scrapie replication in the peritoneum) to the thoracic spinal cord. However, in non-splenectomised mice, the major neuroinvasive pathway is clearly from spleen to thoracic cord because i.p. incubation periods are shorter and replication in the thoracic cord starts correspondingly earlier than in splenectomised mice. Studies of splenectomy at different times after i.p. infection show that pathogenesis becomes independent of the spleen once infection has initiated scrapie replication in the spinal cord. The simplest interpretation of all the evidence favours the spread of scrapie infection along splenic nerve fibres to the thoracic spinal cord. The same neuroinvasive pathway is suggested by the findings using the s.c. and i.v. routes of infection. In addition it was found that the 100-fold greater efficiency of infection by the i.v. compared to the i.p. route was entirely dependent on the spleen, because splenectomy before i.v. infection reduced its eff...Continue Reading

References

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Jan 1, 1978·Journal of Comparative Pathology·R H Kimberlin, C A Walker
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Citations

Jan 1, 1994·Archives of Virology·R I CarpP D Mehta
Mar 20, 2010·Histochemistry and Cell Biology·Gauthier DorbanNadine Antoine
Mar 1, 1989·Virus Research·R H Kimberlin, C A Walker
Jan 1, 1996·Brain Research Bulletin·H F Baker, R M Ridley
Mar 9, 2004·Journal of Comparative Pathology·G McGovernM Jeffrey
Aug 6, 2013·The Journal of Infection·Peter-Christian KlöhnJohn Collinge
Oct 12, 2001·Journal of Neuroscience Methods·P CalvoP Couvreur
Oct 2, 2004·Nature Reviews. Drug Discovery·Neil R Cashman, Byron Caughey
Sep 19, 2006·Nature Reviews. Microbiology·Adriano Aguzzi, Mathias Heikenwalder
May 11, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Akihiko UrayamaClaudio Soto
Jun 27, 2008·Journal of Virology·Sevda Cordier-Dirikoc, Joëlle Chabry
Feb 12, 2002·Journal of Virology·Jérôme FolletJean-Yves Cesbron
Jul 24, 2010·Interdisciplinary Perspectives on Infectious Diseases·Sílvia SisóMartin Jeffrey
Sep 27, 2007·BMC Veterinary Research·Christine KratzelMichael Beekes
Feb 24, 2012·PLoS Pathogens·Rocio Castro-SeoanePeter-Christian Klöhn
Mar 12, 2010·Uirusu·Ken'ichi HagiwaraKentaro Hanada
Jun 8, 2007·Emerging Infectious Diseases·Brent L RaceRichard E Race
Jan 25, 2013·Viruses·Barry M Bradford, Neil A Mabbott
Apr 3, 1999·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·P Beauvais, T Billette de Villemeur
Nov 6, 1998·Brain Pathology·A J RaeberA Aguzzi
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Jul 11, 2002·The American Journal of Pathology·Einar M SigurdssonThomas Wisniewski
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Oct 7, 2009·Neurobiology of Disease·Gianpietro BondiolottiSilvio R Bareggi
Feb 23, 2005·Immunity·Adriano Aguzzi, Mathias Heikenwalder
Jan 5, 2010·Neurobiology of Aging·Dana Avrahami, Ruth Gabizon

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