PMID: 15383605Sep 24, 2004Paper

The role of the Th2 CC chemokine ligand CCL17 in pulmonary fibrosis

The Journal of Immunology : Official Journal of the American Association of Immunologists
J A BelperioM P Keane

Abstract

Increasing evidence suggests that the development of pulmonary fibrosis is a Th2-mediated process. We hypothesized that the CC chemokines that are associated with a Th2 profile (CCL17 and CCL22) have an important role in the development of pulmonary fibrosis. We measured CCL17 and CCL22 during the pathogenesis of bleomycin-induced pulmonary fibrosis. We found that both CCL17 and CCL22 were significantly elevated through day 20 as compared with control mice. Peak expression of CCL22 preceded the peak levels of CCL17, as measured by real-time quantitative PCR. CCR4 is the receptor for CCL17 and CCL22 therefore, to further characterize the role of CCL17 and CCL22, we measured CCR4 mRNA in lung tissue of bleomycin-treated mice by real-time quantitative PCR. CCR4 was significantly elevated in bleomycin-treated mice as compared with control mice. Immunolocalization demonstrated that CCR4 was expressed predominantly on macrophages. Neutralization of CCL17, but not CCL22, led to a reduction in pulmonary fibrosis. Immunolocalization of bleomycin-treated lung tissue and human idiopathic pulmonary fibrosis tissue specimens showed that epithelial cells expressed CCL17. These findings demonstrate a central role for Th2 chemokines and the ma...Continue Reading

References

Oct 1, 1986·Biochemical Medicine and Metabolic Biology·S N GiriB J Marafino
Jan 1, 1988·Experimental Lung Research·D M HydeM Y Stovall
Sep 1, 1989·The Journal of Experimental Medicine·P F PiguetP Vassalli
May 1, 1983·The American Review of Respiratory Disease·D J SchrierB M McGarry
Sep 1, 1993·American Journal of Respiratory Cell and Molecular Biology·J K BrielandJ C Fantone
Jun 15, 1996·The Journal of Clinical Investigation·D A ArenbergR M Strieter
Dec 1, 1996·American Journal of Respiratory Cell and Molecular Biology·R E SmithS L Kunkel
Nov 17, 1998·American Journal of Respiratory and Critical Care Medicine·S T UhD W Riches
Dec 3, 1998·The Journal of Clinical Investigation·H YoneyamaK Matsushima
Mar 24, 1999·Journal of Leukocyte Biology·M HeleneA M Kaplan
Dec 1, 1999·Inflammatory Bowel Diseases·S Romagnani
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A TokudaK Matsushima
Jun 8, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C D MillsA M Hill
Aug 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T SekiyaK Hirai
Feb 15, 2001·Annals of Internal Medicine·M SelmanUNKNOWN American College of Chest Physicians
Jun 8, 2001·The Journal of Clinical Investigation·P Panina-BordignonF Sinigaglia
Jun 19, 2001·American Journal of Physiology. Lung Cellular and Molecular Physiology·M P KeaneR M Strieter
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·M P KeaneR M Strieter
Jan 25, 2002·Respiratory Research·Moisés Selman, Annie Pardo
Apr 17, 2002·American Journal of Respiratory and Critical Care Medicine·Eishi MiyazakiTomiyasu Tsuda
Aug 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jane M SchuhCory M Hogaboam
Oct 3, 2002·American Journal of Respiratory Cell and Molecular Biology·John A BelperioMichael P Keane
Aug 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia JakubzickCory M Hogaboam
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jill E KolodsickBethany B Moore

❮ Previous
Next ❯

Citations

Oct 22, 2005·Infection and Immunity·Kristin J Carpenter, Cory M Hogaboam
Jul 29, 2006·FEBS Letters·Yi-Ching LeeAnil B Mukherjee
Nov 28, 2006·Inhalation Toxicology·K Monica LeeKathy M Gideon
Aug 23, 2008·Journal of Leukocyte Biology·Mark C SiracusaAlan L Scott
Apr 29, 2009·Laboratory Investigation; a Journal of Technical Methods and Pathology·George P ChristophiPaul T Massa
Jan 25, 2012·Journal of Toxicologic Pathology·Toshinori YoshidaTakanori Harada
Nov 20, 2012·Journal of Leukocyte Biology·Sandra Lo ReFrançois Huaux
Feb 11, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Robert V LumsdenMichael P Keane
Feb 1, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·Tereza TomankovaMingyao Liu
Nov 22, 2015·Genome Medicine·Kartiek KanduriRiitta Lahesmaa
Jan 8, 2016·Chinese Journal of Integrative Medicine·Mao-Qiang ManPeter M Elias
May 6, 2016·American Journal of Respiratory Cell and Molecular Biology·Saeed KolahianDominik Hartl
Aug 16, 2016·The Journal of Clinical Investigation·Adrian AchuthanJohn A Hamilton
Jan 19, 2019·Advanced Healthcare Materials·Claire E WitherelKara L Spiller
Mar 3, 2007·The Journal of Clinical Investigation·Alessia Meneghin, Cory M Hogaboam
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine M FreemanStephen W Chensue
Mar 27, 2007·American Journal of Respiratory and Critical Care Medicine·Athol U Wells, Cory M Hogaboam
Mar 5, 2008·The Journal of Experimental Medicine·Elizabeth A JacobsenJames J Lee
Mar 4, 2008·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Minoru Hasegawa
Mar 3, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Gianluca Bagnato, Sergio Harari
Nov 11, 2017·American Journal of Rhinology & Allergy·Charlie PalmerCarl Atkinson
Jun 20, 2018·The Journal of Clinical Investigation·Shin-Ichi NurekiMichael F Beers
Mar 27, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alessandro VenosaMichael F Beers
Apr 27, 2019·The Journal of Biological Chemistry·Yijing GuoZhong Wang
Sep 15, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mi So KimSung Woo Park
Oct 4, 2019·The Journal of Pathology·Yi-Ting ChenShuei-Liong Lin
Nov 30, 2019·Experimental and Therapeutic Medicine·Lucia TurianováTatiana Betáková
Nov 23, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Traci L NessSteven L Kunkel
Jul 16, 2008·European Journal of Immunology·Makoto IshiiSteven L Kunkel
Nov 9, 2010·American Journal of Respiratory Cell and Molecular Biology·Laszlo FarkasMartin Kolb
Oct 22, 2009·Experimental Lung Research·Kaspar RemundAnnette Boehler
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sun YingChris Corrigan
Apr 20, 2014·Protein Engineering, Design & Selection : PEDS·John W KehoeJohn C Wheeler
Jan 18, 2012·International Journal of Radiation Biology·Willie J BrickeyJenny P-Y Ting
Apr 20, 2016·The Journal of Cell Biology·Joana CapoteMelissa J Spencer
Sep 22, 2017·Scientific Reports·Natalia Marek-TrzonkowskaPiotr Trzonkowski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Immunology : Official Journal of the American Association of Immunologists
M P KeaneR M Strieter
American Journal of Respiratory Cell and Molecular Biology
J A BelperioM P Keane
American Journal of Respiratory and Critical Care Medicine
Y TaookaM Yamakido
© 2021 Meta ULC. All rights reserved