PMID: 12757981May 22, 2003Paper

The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy

Diabetes Research and Clinical Practice
F SugawaraYutaka Seino

Abstract

TSC-22 is a leucine zipper transcriptional factor and expression of the TSC-22 gene is highly induced by TGF-beta treatment. We estimated the frequency of the -396 A/G polymorphism of the TSC-22 gene with an Alu I-Restriction fragment length polymorphism (RFLP) method in 498 Japanese subjects with type 2 diabetes mellitus. We also determined the promoter activity. The diabetic patients with the AA genotype had a significantly higher incidence of the diabetic nephropathy (vs. the AG genotype, P<0.05, odds ratio: 1.95; 95% confidence intervals 1.14-3.33). There was no significant difference in the promoter activity between the fragments with -396A and -396G. These findings suggest that the TSC-22 gene (-396) A allele is associated with an increasing risk of the diabetic nephropathy.

References

May 24, 1996·Biochemical and Biophysical Research Communications·P JayP Berta
Jan 20, 1999·Kidney International·N IsmailE Ritz
Jan 28, 1999·Biochemical and Biophysical Research Communications·R WatanabeY Seino
Jul 25, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·H A KesterC L Mummery
Sep 29, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Y AkaiM Kanauchi
Nov 2, 2001·Internal Medicine·F SugawaraY Seino
Nov 2, 2001·Diabetes Research and Clinical Practice·S Baba, UNKNOWN J-MIND Study Group

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Citations

Oct 27, 2005·Diabetes·Kathryn Gogolin EwensRichard S Spielman
Jan 25, 2013·Nephron. Clinical Practice·Isabelle ChapdelaineStéphan Troyanov
Sep 19, 2006·Genetics in Medicine : Official Journal of the American College of Medical Genetics·John P A Ioannidis, Fotini K Kavvoura
Sep 3, 2003·Diabetes/metabolism Research and Reviews

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