PMID: 6407956Jul 1, 1983Paper

The role of the urea cycle and polyamines in albumin synthesis

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
M OratzB Matarese

Abstract

Albumin synthesis is stimulated by those amino acids which increase urea synthesis and membrane bound polysome aggregation. Ornithine, an amino acid not incorporated into protein and produced from arginine in the urea cycle, is an albumin-stimulating amino acid and is the precursor of the polyamines, and we have shown that the polyamine spermine promotes bound polysome aggregation. To test the concept that ureogenesis with its generation of ornithine might play a key role in albumin synthesis regulation via the polyamine pathway, isolated livers from fasted donors were perfused with ornithine, alpha-difluoromethyl ornithine (DFMO), and spermine. In control experiments, albumin synthesis was 13.4 +/- 0.8 mg per 100 gm liver per hr and polysome aggregation was 47%. These were increased in the presence of ornithine (26.0 +/- 2.6 mg and 59%); if the livers were preperfused with DFMO before the addition of ornithine, then the expected increase in albumin synthesis and polysome reaggregation did not occur (16.3 +/- 1.4 mg and 47%). However, if spermine was present with DFMO during the preperfusion, then the addition of ornithine had the expected effect (albumin synthesis = 26.1 +/- 1.2 mg and polysome aggregation = 62%). This suggest...Continue Reading

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Citations

Sep 11, 1992·International Journal of Sport Nutrition·L R BucciJ M Pivarnik
Feb 1, 1995·Alcoholism, Clinical and Experimental Research·I A ShibleyS N Pennington
Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M A RothschildS S Schreiber
Jun 1, 2005·Amino Acids·C ChiarlaJ H Siegel
Mar 15, 2018·American Journal of Physiology. Renal Physiology·James G AthertonErnő Lindner
Jan 1, 1987·Annals of the New York Academy of Sciences·M A RothschildS S Schreiber
Aug 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S NishiguchiK Kobayashi
Nov 20, 2019·Animals : an Open Access Journal From MDPI·Cristina SaroFrancisco Javier Giráldez
Nov 7, 2000·British Journal of Anaesthesia·J P NicholsonG R Park
May 27, 2005·The Journal of Surgical Research·Brygida BeckJashovam Shani

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