PMID: 37452Apr 1, 1979

The role of thiamine in nervous tissue

Neurochemical Research
J R Cooper, J H Pincus

Abstract

The possibility that thiamine (vitamin B1) has a role in nervous tissue that is independent of its well-documented coenzyme function is discussed. After reviewing the localization and metabolism of the vitamin and its phosphate esters, the effects of either thiamine deprivation or antimetabolites of thiamine on conduction and transmission, and the relationship between thiamine triphosphate and the genetic, neurological disease, subacute necrotizing encephalomyelopathy (Leigh's disease), it is suggested that despite the lack of hard evidence, it is likely that the vitamin possesses this alternate function.

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Thiamine Deficiency
Thiamine Mononitrate
Berolase
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Synaptic Transmission
Thiamin Pyrophosphokinase
Nerve Conduction Function
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Leigh Disease
Pyrithiamine

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