PMID: 11927969Apr 3, 2002Paper

The role of thymidine phosphorylase and thrombospondin-1 in angiogenesis and progression of intrahepatic cholangiocarcinoma

International Journal of Surgical Pathology
Shin-Ichi AishimaMasazumi Tsuneyoshi

Abstract

Thymidine phosphorylase (TP), an important regulator of angiogenesis, is correlated with progression, metastasis, and prognosis in various types of tumor. In contrast, both positive and negative effects of thrombospondin-1 (TSP-1) on angiogenesis have been reported. In the present study, we examined the expression of TP and TSP-1 in carcinoma cells in 67 primary intrahepatic cholangiocarcinomas (ICCs) immunohistochemically and its correlation with angiogenesis, clinicopathological features, and prognosis. Twenty-six (38.8%) cases were classified as exhibiting positive TP expression. TP expression showed a significant correlation with vascular invasion, lymphatic permeation, perineural invasion, and lymph node metastasis. Thirty-four (50.7%) cases were classified as exhibiting positive TSP-1 expression. TSP-1 expression was significantly correlated with only lymphatic permeation. The microvessel count in positive TP expression cases was significantly higher than that in negative cases. In contrast, the microvessel count in negative TSP-1 expression cases was significantly higher than that in positive cases. Survival in patients who were positive for both TP and TSP-1 expression was significantly poor. Our results suggest that th...Continue Reading

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Citations

Dec 17, 2009·Future Oncology·Giuseppe ToniniDaniele Santini
Dec 17, 2008·World Journal of Gastroenterology : WJG·Alphonse-E Sirica
Apr 1, 2010·World Journal of Gastroenterology : WJG·Jongkonnee ThanasaiMasanao Miwa
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Jun 2, 2020·Cell Biochemistry and Function·Shuangling LiChangqing Xu
Jul 26, 2006·World Journal of Gastroenterology : WJG·Jongkonnee ThanasaiMasanao Miwa
Jul 20, 2007·Cancer Research·Gary PotikyanChristopher T Denny

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