PMID: 6411992Jul 1, 1983Paper

The role of thyrotrophin releasing hormone in the diagnosis of isolated gonadotrophin deficiency

Journal of Steroid Biochemistry
I M SpitzS Trestian

Abstract

We studied the response of PRL and TSH to thyrotrophin-releasing hormone (TRH) in 15 boys with delayed adolescence and 6 male subjects with isolated gonadotrophin deficiency (IGD). TRH tests were repeated in the IGD subjects during and 1 month following hCG treatment. Male IGD subjects showed a significantly decreased basal and TRH induced PRL response compared to male controls and subjects with delayed adolescence. Human chorionic gonadotrophin (HCG) treatment of male IGD subjects restored basal and stimulated PRL levels to the range of normal controls. This was, presumably, an estrogenic effect since non aromatizable androgens did not increase the PRL response; moreover, the antioestrogen, clomiphene, decreased the PRL response when given with HCG. The TSH response to TRH in delayed adolescents was increased as compared to adult male controls and IGD subjects and was similar to adult female controls. HCG treatment of IGD subjects had no effect on basal nor peak TSH levels, although ethinyl oestradiol did increase the TSH response in two IGD subjects. These studies show that the PRL and TSH responses to TRH may differentiate delayed adolescence from IGD. The increased TSH response to TRH in delayed adolescence as compared to a...Continue Reading

References

Apr 24, 1971·British Medical Journal·B J OrmstonR Hall
Jul 3, 1971·Lancet·B J OrmstonR Hall
Jun 1, 1973·The Journal of Clinical Endocrinology and Metabolism·L S JacobsW H Daughaday
Nov 1, 1973·The Journal of Clinical Endocrinology and Metabolism·J S RakoffS S Yen
Sep 1, 1973·The Journal of Clinical Endocrinology and Metabolism·H E CarlsonW H Daughaday
Feb 1, 1974·European Journal of Clinical Investigation·J Weeke
Oct 1, 1974·The Journal of Endocrinology·S H ShinC Howitt
Feb 1, 1972·The Journal of Clinical Endocrinology and Metabolism·P J Snyder, R D Utiger
Dec 1, 1973·The Journal of Clinical Endocrinology and Metabolism·M T Buckman, G T Peake
Oct 1, 1971·The Journal of Clinical Endocrinology and Metabolism·E D HaiglerC M Baugh
Sep 1, 1984·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·I M SpitzS Shilo
Feb 1, 1974·The Journal of Clinical Investigation·S S YenT M Siler

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Citations

Aug 1, 1988·European Journal of Pediatrics·H J HirschI M Spitz
Apr 1, 1997·Pediatric Clinics of North America·D M Styne

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